Evidence map›Paper›PMID 40463394›Full record

ArticleBioactive materials2025

Application of bioactive materials primary cilia as a novel delivery vehicle.

Ayan K Barui, Farideh Amirrad, Vansh Goel, Sharareh Ohadi, Rajasekharreddy Pala, Ashraf M Mohieldin, Andromeda M Nauli, Surya M Nauli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ayan K BaruiDepartment of Biomedical and Pharmaceutical Sciences, Chapman University, Irvine, CA, 92618, USA.
Farideh AmirradDepartment of Biomedical and Pharmaceutical Sciences, Chapman University, Irvine, CA, 92618, USA.
Vansh GoelDepartment of Biomedical and Pharmaceutical Sciences, Chapman University, Irvine, CA, 92618, USA.
Sharareh OhadiDepartment of Biomedical and Pharmaceutical Sciences, Chapman University, Irvine, CA, 92618, USA.
Rajasekharreddy PalaDepartment of Biomedical and Pharmaceutical Sciences, Chapman University, Irvine, CA, 92618, USA.
Ashraf M MohieldinDepartment of Biomedical and Pharmaceutical Sciences, Chapman University, Irvine, CA, 92618, USA.
Andromeda M NauliDepartment of Biomedical Sciences, Homer Stryker M.D. School of Medicine, Western Michigan University, Kalamazoo, MI, 49007, USA.
Surya M NauliDepartment of Biomedical and Pharmaceutical Sciences, Chapman University, Irvine, CA, 92618, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary cilia are hair-like structured cell organelles functioning as cellular antennae with chemosensory and mechanosensory roles. Dysfunction of cilia results in ciliopathies, including renovascular diseases (polycystic kidneys, hypertension, aneurysm), mental impedances (Alzheimer's disease, Parkinson's disease, dementia), metabolic diseases (obesity, developmental skeleton defects), blindness, and so on. With a diameter of 150 nm, cilia can be cleaved, released and circulated in the body as injury biomarkers. We here assessed the potential use of isolated cilia as a novel delivery vehicle. Cilia were isolated from renal epithelial cells, and a specific-targeting chemotherapeutic was designed on the cilia. The data show a remarkable property of cilia to significantly inhibit disease progression with reduced toxicity. These findings emphasize the prospective biomedical applications of primary cilia in generating novel drug, gene, protein, and other delivery systems to treat diverse pathological conditions. While there are many synthetic drug delivery vehicles, our studies demonstrate for the first time that physiologically produced primary cilia can be adapted as a unique carrier system.

Indexed as

Drug deliveryExosomeNanotechnologyNovel delivery vehiclePrimary cilia

Identifiers

PMID40463394
PMCPMC12127868

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.