ArticleFrontiers in immunology2025
Aqueous humor cytokines levels and illuminated microcatheter-assisted circumferential trabeculotomy outcome in open-angle glaucoma patients: a 24-month prospective study.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Comparative One-Year Outcomes of T-HookJournal of clinical medicine · 2026Article
- Two-year outcomes of modified external suture trabeculotomy for Chinese open-angle glaucoma patients.Frontiers in medicine · 2026Article
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5 authors.
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Abstract
Purpose: To investigate the influence of aqueous humor cytokines levels on the failure of illuminated microcatheter-assisted circumferential trabeculotomy (MAT) in open-angle glaucoma (OAG) patients. Methods: This was a prospective case series with a follow-up period of 24 months. General information and ocular examinations were recorded. Aqueous humor was collected at the time of surgery. Eight aqueous humor cytokines were analyzed: CCL2, VCAM-1, ICAM-1, IL-6, IL-8, IL-10, CXCL10 and G-CSF. Bioinformatics analysis was used to explore the protein network and the possible pathways related to OAG. Surgical failure was defined as a requirement for glaucoma reoperation or intraocular pressure (IOP) greater than 21mmHg with more than 3 topical antiglaucoma medications at 24-month follow-up. Results: Sixty-five eyes were enrolled (58 success and 7 failure). The levels of CCL2, ICAM-1, IL-6 and CXCL10 in aqueous humor were significantly higher in the surgical failure group ( Conclusion: Higher concentrations of CCL2, ICAM-1, IL-6 and CXCL10 in the aqueous humor were related to the failure of MAT surgery in OAG patients, and chemokine signaling pathway might be associated with the surgical outcome.
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