ArticleFrontiers in immunology2025
Single-cell RNA sequencing identifies two fibroblast subtypes and a Trem2
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- From hemodynamic stress to inflammatory wall remodeling in intracranial aneurysms.Frontiers in molecular biosciences · 2026Review
- Spatial Transcriptomics RevealsbioRxiv : the preprint server for biology · 2025Article
- Targeting the CD47-TSP1 Axis in Abdominal Aortic Aneurysm: A Novel Immunotherapeutic Approach.International journal of molecular sciences · 2025Review
- Molecular mechanisms and genetic predisposition to osteoarthritis and osteosarcoma through Mendelian inheritance patterns.Discover oncology · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Aortic aneurysm is a potentially fatal condition. Although contemporary studies have established that this disease triggers an inflammatory response, reduces smooth muscle cells, and induces extracellular matrix remodeling, the involvement of inflammatory cells and associated signaling pathways in the progression and expansion of aneurysms is well-documented. However, clinical treatments utilizing anti-inflammatory therapies have proven ineffective. Methods: In this study, we employed a classic mouse model of abdominal aortic aneurysm (AAA) to compare the cellular composition and functional phenotypes of normal and AAA cells within a comprehensive single-cell microenvironment. Results: Our findings revealed distinct evolutionary pathways for both fibroblasts and macrophages, leading to the identification of specific fibroblast subtypes (Fib_Apoc1
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