ArticleRSC advances2025
Innovative sensors with selectivity enhancement by molecularly imprinted polymers for the concurrent quantification of donepezil and memantine.
Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Smartphone based colorimetric method for determination of memantine via schiff's base reaction with ascorbic acid.Scientific reports · 2026Article
- Eco-Friendly Spectrophotometric Methods for Resolving the Spectral Inference of Benzalkonium Chloride During Alcaftadine and Ketorolac Tromethamine Quantification.Analytical science advances · 2025Article
- Graphene-cobalt hexacyanoferrate modified sensor doped with molecularly imprinted polymer for selective potentiometric determination of bupropion.Scientific reports · 2025Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ion-selective sensors are widely employed in various pharmaceutical, environmental, and biological analytical applications due to their simplicity, cost-effectiveness, and rapid response times. They suffer from some challenges though. These challenges may arise from the selective sensing process that can be hindered by interference from ions with similar charges or suitable lipophilicity. Solid contact type due to water layer formation between the sensing surfaces may also appear as an obstacle. This work is dedicated to overcoming the selectivity issue using the molecularly imprinted polymer (MIP) approach to determine Donepezil (DON) and Memantine (MEM) in their combined pharmaceutical formulation. Precipitation polymerization approach was employed for the preparation of the MIP for each drug. The resulting MIPs were thoroughly examined using various characterization methods. The potential response of the proposed sensors was stabilized by applying graphene nanoplatelets as an ion-to-electron transducer layer. This layer prevented the formation of the water layer, improved the responses, and enhanced charge transfer. Two sensors featuring different cationic exchangers were designed for the selective determination of donepezil, for which one sensor was developed for memantine analysis by adding the corresponding MIPs to the membrane components. The achieved detection limits were 5.01 × 10
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Registered trials
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