Evidence map›Paper›PMID 40463280›Full record

ArticlebioRxiv : the preprint server for biology2025

Spatial epigenomic niches underlie glioblastoma cell state plasticity.

Sam Kint, Subhi Talal Younes, Shuozhen Bao, Gretchen Long, David Wouters, Erin Stephenson, Xing Lou, Mei Zhong, Di Zhang, Graham Su and 13 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Sam KintArnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
Subhi Talal YounesDepartment of Pediatrics, Baylor College of Medicine, Houston, TX, 77030, United States of America.
Shuozhen BaoDepartment of Biomedical Engineering, Yale University, New Haven, CT, 06520, United States of America.
Gretchen LongDepartment of Neurosurgery, Yale University, New Haven, CT, 06520, United States of America.
David WoutersDepartment of Human Genetics, University of Leuven, KU Leuven, Leuven, 3000, Belgium.
Erin StephensonDepartment of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB T2N 2T9, Canada.
Xing LouDepartment of Biomedical Engineering, Yale University, New Haven, CT, 06520, United States of America.
Mei ZhongDepartment of Cell Biology, Yale University, New Haven, CT, 06520, United States of America.
Di ZhangDepartment of Biomedical Engineering, Yale University, New Haven, CT, 06520, United States of America.
Graham SuDepartment of Biomedical Engineering, Yale University, New Haven, CT, 06520, United States of America.
Archibald EnninfulDepartment of Biomedical Engineering, Yale University, New Haven, CT, 06520, United States of America.
Mingyu YangDepartment of Biomedical Engineering, Yale University, New Haven, CT, 06520, United States of America.
Huey-Miin ChenDepartment of Pediatrics, Baylor College of Medicine, Houston, TX, 77030, United States of America.
Katrina EllestadArnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
Colleen AndersonArnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
Jennifer MoliternoDepartment of Neurosurgery, Yale University, New Haven, CT, 06520, United States of America.
John KellyArnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
Jennifer A ChanArnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
Alejandro SifrimDepartment of Human Genetics, University of Leuven, KU Leuven, Leuven, 3000, Belgium.
Jiangbing ZhouDepartment of Biomedical Engineering, Yale University, New Haven, CT, 06520, United States of America.
Ana NikolicArnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
Rong FanDepartment of Biomedical Engineering, Yale University, New Haven, CT, 06520, United States of America.
Marco GalloArnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.ORCID 0000-0002-8451-8207

Funding

Spatiotemporal Tumor Analytics for Guiding Sequential Targeted-Inhibitor: Immunotherapy Combinations (ST-Analytics)U54CA274509 · NCI · INSTITUTE FOR SYSTEMS BIOLOGY · PI Rong Fan · 2022 to 2026
$15.6M
Tech Core 2U54CA268083 · NCI · JOHNS HOPKINS UNIVERSITY · PI Pei-Hsun wu · 2022 to 2026
$10.2M
Ex vivo analysis of human brain tumor cells in a microvascular niche modelR01CA245313 · NCI · YALE UNIVERSITY · PI FAN, RONG, ZHOU, JIANGBING · 2020 to 2024
$2.6M
NCI NIH HHS R01 CA245313NCI NIH HHS U54 CA268083NCI NIH HHS U54 CA274509
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

brain tumorscell state transitionsepigeneticsepigenomicsglioblastomagliomaplasticityscATANCspatial ATACSpatial genomicsspatial multiomics

Identifiers

PMID40463280
PMCPMC12132327

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.