ArticlebioRxiv : the preprint server for biology2025
Normative Brain Entropy Across the Lifespan.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
3 authors.
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Abstract
Brain entropy (BEN), a measure of the complexity and irregularity of neural has emerged as a promising marker for cognitive and clinical traits. However, normative lifespan trajectories of BEN remain underexplored. In this study, we investigated age-related changes in BEN across the human lifespan using Sample Entropy (SampEn). BEN was estimated from resting-state fMRI data collected from multiple Human Connectome Project cohorts (N = 2,415, ages 8-89 years), and normative growth curves were modeled using the GAMLSS framework. Results revealed a nonlinear increase in average BEN from childhood to older adulthood, with females exhibiting significantly higher BEN than males. Regional and network-level analyses confirmed similar age-related patterns.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.