Evidence map›Paper›PMID 40463234›Full record

ArticlebioRxiv : the preprint server for biology2025

Large-Scale Genomic Analysis of CpG-Mediated Immunogenicity in Bacteriophages and a Novel Predictive Risk Index.

Lukeman Kharrat, Camilo A Garcia-Botero, Wade Ingersoll, Tiffany Luong, Alejandro Reyes, Dwayne R Roach

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lukeman KharratDepartment of Biology, San Diego State University, San Diego, CA 92182, USA.
Camilo A Garcia-BoteroDepartment of Biological Sciences, Universidad de los Andes, Bogotá, 111711, Colombia.
Wade IngersollDepartment of Biology, San Diego State University, San Diego, CA 92182, USA.
Tiffany LuongDepartment of Biology, San Diego State University, San Diego, CA 92182, USA.
Alejandro ReyesDepartment of Biological Sciences, Universidad de los Andes, Bogotá, 111711, Colombia.
Dwayne R RoachDepartment of Biology, San Diego State University, San Diego, CA 92182, USA.ORCID 0000-0002-2069-8915

Funding

Pharmacokinetics and Pharmacodynamics of Mechanistically Aware Phage CocktailsR01AI177997 · NIAID · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Nicholas Michael Smith · 2024 to 2026
$2.2M
NIAID NIH HHS R01 AI177997
6 · The paper itself

Abstract

Bacteriophage (phage) therapy is a promising alternative to antibiotics, yet phage-induced immune responses can affect treatment efficacy. However, current methods for assessing phage immunogenicity are limited, hindering the development of safer, more effective therapies. Here, we introduce the

Indexed as

CpG motifshost-phage interactionimmune responsepattern recognitionphage therapysafety

Identifiers

PMID40463234
PMCPMC12132194

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.