Evidence map›Paper›PMID 40463186›Full record

ArticlebioRxiv : the preprint server for biology2025

Unmasking Convergent Oxycodone Seeking and Consumption Driving Augmented Intake during Extended Access to Oral Operant Self-Administration.

Burt M Sharp, Hao Chen

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Burt M SharpDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38103, USA.
Hao ChenDepartment of Pharmacology, Addiction Science, and Toxicology, University of Tennessee Health Science Center, Memphis, TN 38103, USA.

Funding

Genetics of oxycodone intake in a hybrid rat diversity panel.U01DA053672 · NIDA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI CHEN, HAO, SHARP, BURT M · 2021 to 2025
$3.4M
NIDA NIH HHS U01 DA053672
6 · The paper itself

Abstract

Individual vulnerability to opioid intake escalation is a critical but poorly understood aspect of addiction. Using genetically diverse inbred rat strains, we investigated operant oral oxycodone self-administration, identifying 'Augmenter' phenotypes that dramatically increased consumption during extended (16h vs. 4h) access-a vulnerability not predicted by standard motivation tests. A key innovation was applying lick microstructure analysis (LMA) to operationally distinguish 'consumption' from 'seeking' lick clusters within the inter-reward interval. During extended access, Augmenters of both sexes exhibited a striking surge in the

Identifiers

PMID40463186
PMCPMC12132477

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.