ArticlebioRxiv : the preprint server for biology2025
Unmasking Convergent Oxycodone Seeking and Consumption Driving Augmented Intake during Extended Access to Oral Operant Self-Administration.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Individual vulnerability to opioid intake escalation is a critical but poorly understood aspect of addiction. Using genetically diverse inbred rat strains, we investigated operant oral oxycodone self-administration, identifying 'Augmenter' phenotypes that dramatically increased consumption during extended (16h vs. 4h) access-a vulnerability not predicted by standard motivation tests. A key innovation was applying lick microstructure analysis (LMA) to operationally distinguish 'consumption' from 'seeking' lick clusters within the inter-reward interval. During extended access, Augmenters of both sexes exhibited a striking surge in the
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