ArticlebioRxiv : the preprint server for biology2025
Resistance to the KRAS
Daniel R Principe, Jeffrey H Becker, Anastasia E Metropulos, Alejandra M Marinelarena, Thao D Pham, Alexandre F Aissa, Hidayatullah G Munshi
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
7 authors.
Daniel R PrincipeDepartment of Medicine, Physician Scientist Training Program, University of Wisconsin, Madison, WI.ORCID 0000-0003-4355-6597 Jeffrey H BeckerDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Anastasia E MetropulosDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Alejandra M MarinelarenaDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Thao D PhamDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Alexandre F AissaDivision of Genetics, Department of Morphology and Genetics, Federal University of São Paulo, São Paulo, Brazil.
Hidayatullah G MunshiDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Funding
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9MCo-targeting BET Bromodomain Proteins and MNK Kinases in Pancreatic CancerR01CA265997 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Hidayatullah G. Munshi · 2022 to 2026
$2.4MNU-TRIHO (Northwestern University Translational Research in Hematology-Oncology) Training ProgramT32CA268935 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MAHA H HUSSAIN, Hidayatullah G. Munshi · 2023 to 2026
$985kAugmenting Pancreatic Cancer Immunotherapy via TGFβ Pathway InhibitionF30CA236031 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI PRINCIPE, DANIEL R · 2019 to 2023
$256kBLRD VA I01 BX005595NCI NIH HHS F30 CA236031NCI NIH HHS P30 CA060553NCI NIH HHS R01 CA265997NCI NIH HHS T32 CA268935
6 · The paper itselfAbstract
As many as 90% of human pancreatic ductal adenocarcinoma (PDAC) tumors harbor gain-of-function mutations in the
Indexed as
BET ProteinsDrug ResistanceEpigeneticsKRAS InhibitorPancreatic Cancer
Identifiers
PMID40463163
PMCPMC12132508
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