ArticlebioRxiv : the preprint server for biology2025
Virus-like particle vaccines targeting a key epitope in circumsporozoite protein provide sterilizing immunity against malaria.
Yogesh Nepal, Alexandra Francian, Yevel Flores-Garcia, Bryce T Roberts, Sunil A David, Fidel Zavala, Bryce Chackerian
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
7 authors.
Yogesh NepalDepartment of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
Alexandra FrancianDepartment of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
Yevel Flores-GarciaW. Harry Feinstone Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Bryce T RobertsDepartment of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
Sunil A DavidViroVax LLC, Lawrence, Kansas, USA.
Fidel ZavalaW. Harry Feinstone Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Bryce ChackerianDepartment of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.ORCID 0000-0002-5712-4739 Funding
Unfolded Protein Response and Autophagy in T Helper Cell Effector FunctionP20GM121176 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI June Bryan de la Pena · 2017 to 2026
$24.9MFAIR Data Competency and Machine Learning Readiness for Biomedical ScientistsK12GM088021 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI REBECCA S. HARTLEY, Diane Lidke · 2009 to 2026
$16.4MVirus-like Particle based malaria vaccines targeting vulnerable epitopes in the circumsporozoite proteinR01AI169739 · NIAID · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Bryce C Chackerian · 2023 to 2026
$2.5MNIAID NIH HHS HHSN272201800049CNIAID NIH HHS R01 AI169739NIGMS NIH HHS K12 GM088021NIGMS NIH HHS P20 GM121176
6 · The paper itselfAbstract
Vaccines that target the pre-erythrocytic stage of the malaria lifecycle have the potential to provide sterilizing immunity but must elicit sustained, high-titer antibody responses to completely prevent infection. Most pre-erythrocytic vaccines target circumsporozoite protein (CSP), the major surface antigen on
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PMID40463147
PMCPMC12132212
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