Evidence map›Paper›PMID 40463140›Full record

ArticlebioRxiv : the preprint server for biology2025

Chronic compression drives macrophages toward a pathological pro-tumor state.

Alice Burchett, Hao Chen, Julian Najera, Scott Howard, Meenal Datta

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Alice BurchettDepartment of Aerospace and Mechanical Engineering, University of Notre Dame, IN, USA.ORCID 0000-0003-3751-3478
Hao ChenDepartment of Electrical Engineering, University of Notre Dame, IN, USA.
Julian NajeraDepartment of Aerospace and Mechanical Engineering, University of Notre Dame, IN, USA.
Scott HowardDepartment of Electrical Engineering, University of Notre Dame, IN, USA.ORCID 0000-0003-3246-6799
Meenal DattaDepartment of Aerospace and Mechanical Engineering, University of Notre Dame, IN, USA.

Funding

Establishing an immune mechanomeR35GM151041 · NIGMS · UNIVERSITY OF NOTRE DAME · PI Meenal Datta · 2023 to 2026
$1.7M
NIGMS NIH HHS R35 GM151041
6 · The paper itself

Abstract

Macrophages comprise a significant portion of the glioblastoma tumor microenvironment and are essential in promoting immunosuppression and tumor progression. Solid tumors such as glioblastoma generate solid stress as they expand, creating a compressive microenvironment for mechanosensitive immune cells including macrophages. Macrophages are known to respond to various mechanical stimuli but have not yet been studied in the context of chronic compression observed in growing tumors. Here, we used a custom

Indexed as

fluorescence lifetime imaging (FLIM)immunomechanicsmechano-immunologymetabolismmorphologyMyeloid cellsphagocytosispolarizationRNA sequencingsolid stress

Identifiers

PMID40463140
PMCPMC12132300

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.