Evidence map›Paper›PMID 40463117›Full record

ArticlebioRxiv : the preprint server for biology2025

Species-specific, multifaceted venom resistance in

Matthew Holding, Dante Disharoon, Laura Haynes, Bipin Chakravarthy Paruchuri, M Hao Hao Pontius, Krista Golden, Jordan A Shavit, Karl Desch, David Ginsburg, Anirban Sen Gupta and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Matthew HoldingLife Sciences Institute, University of Michigan, Ann Arbor, MI.ORCID 0000-0003-3477-3012
Dante DisharoonDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0002-4896-674X
Laura HaynesLife Sciences Institute, University of Michigan, Ann Arbor, MI.ORCID 0000-0002-2237-659X
Bipin Chakravarthy ParuchuriDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0001-7285-023X
M Hao Hao PontiusDepartment of Pediatrics, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-1826-4533
Krista GoldenDepartment of Pediatrics, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-1679-797X
Jordan A ShavitDepartment of Pediatrics, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-2874-4904
Karl DeschDepartment of Pediatrics, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-0392-4033
David GinsburgLife Sciences Institute, University of Michigan, Ann Arbor, MI.ORCID 0000-0002-6436-8942
Anirban Sen GuptaDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0002-5773-0667
Yolanda CruzOberlin College Department of Biology, Oberlin, OH 44074, USA.
Danielle H DrabeckDepartment of Ecology, Evolution, and Behavior, University of Minnesota, Twin Cities.ORCID 0000-0002-7096-3254

Funding

Training Research Educators in Minnesota (TREM) whilst increasing diversityK12GM119955 · NIGMS · UNIVERSITY OF MINNESOTA · PI David Irwin Greenstein, Julia Willett · 2017 to 2026
$6.5M
Genetic and therapeutic studies of hemostatic and thrombotic disorders using zebrafishR35HL150784 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jordan A. Shavit · 2020 to 2026
$5.4M
Heteromutivalent Peptide-Lipid Nanoconstructs as Artificial Platelet AnaloguesR01HL121212 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI SEN GUPTA, ANIRBAN · 2014 to 2024
$4.1M
The Molecular Genetics of HemostasisR35HL171421 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David Ginsburg · 2024 to 2026
$2.8M
The Molecular Genetics of Von Willebrand Factor SecretionR01HL172780 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Karl C Desch · 2024 to 2026
$1.8M
NHLBI NIH HHS R01 HL121212NHLBI NIH HHS R01 HL172780NHLBI NIH HHS R35 HL150784NHLBI NIH HHS R35 HL171421NIGMS NIH HHS K12 GM119955
6 · The paper itself

Abstract

Interactions between predators and prey are often characterized by strong selection pressures that shape extreme physiological adaptations. Venom resistance in large-bodied South American opossums (Clade Didelphini) is a striking example, as these marsupials prey on venomous snakes and exhibit remarkable resistance to their venom. While resistance is well documented in Didelphini, relatively little is known about venom resistance in the smaller, more diverse members of Didelphidae, which inhabit the same regions and encounter the same predators. Here, we investigate venom resistance in the small-bodied opossum,

Identifiers

PMID40463117
PMCPMC12132390

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.