Evidence map›Paper›PMID 40463115›Full record

ArticlebioRxiv : the preprint server for biology2025

Of condensates and coats - reciprocal regulation of clathrin assembly and the growth of protein networks.

Brandon T Malady, Andromachi Papagiannoula, Advika Kamatar, Susovan Sarkar, Gavin T Lebrun, Liping Wang, Carl C Hayden, Eileen M Lafer, David J Owen, Sigrid Milles and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Brandon T MaladyDepartment of Biomedical Engineering, The University of Texas at Austin, United States.
Andromachi PapagiannoulaLeibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany.
Advika KamatarDepartment of Biomedical Engineering, The University of Texas at Austin, United States.
Susovan SarkarDepartment of Biomedical Engineering, The University of Texas at Austin, United States.
Gavin T LebrunDepartment of Biomedical Engineering, The University of Texas at Austin, United States.
Liping WangDepartment of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, United States.
Carl C HaydenDepartment of Biomedical Engineering, The University of Texas at Austin, United States.
Eileen M LaferDepartment of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, United States.
David J OwenCambridge Institute for Medical Research, University of Cambridge, UK.
Sigrid MillesLeibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany.
Jeanne C StachowiakDepartment of Biomedical Engineering, The University of Texas at Austin, United States.ORCID 0000-0003-2501-142X

Funding

Protein Networks as Synergistic Drivers of Membrane RemodelingR35GM139531 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI Jeanne Casstevens Stachowiak · 2021 to 2026
$4.0M
NIGMS NIH HHS R35 GM139531
6 · The paper itself

Abstract

Clathrin-mediated endocytosis is essential for membrane traffic, impacting a diverse range of cellular processes including cell signaling homeostasis, cell adhesion, and receptor recycling. During endocytosis, invagination of the plasma membrane is coordinated by a network of proteins that recruit and assemble the clathrin coat. Recent work demonstrated that clathrin accessory proteins which arrive early at endocytic sites, such as Eps15 and Fcho2, form phase-separated condensates that recruit downstream machinery, promoting assembly and maturation of clathrin-coated vesicles. However, the mechanisms by which protein condensates regulate - and are regulated by - clathrin assembly remain unclear. Using

Identifiers

PMID40463115
PMCPMC12132507

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.