Evidence map›Paper›PMID 40463096›Full record

ArticlebioRxiv : the preprint server for biology2025

Congenital heart disease missense mutations in the TBX5 DNA-binding domain alter thermal stability and DNA-binding affinity.

Alejandro Rivera-Madera, Edwin G Peña-Martínez, Jean L Messon-Bird, Diego A Pomales-Matos, Oswaldo L Echevarría-Bonilla, Leandro Sanabria-Alberto, Esther A Peterson-Peguero, José A Rodríguez-Martínez

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Alejandro Rivera-MaderaDepartment of Biology, University of Puerto Rico- Río Piedras Campus, San Juan, PR 00931.ORCID 0000-0003-0037-4822
Edwin G Peña-MartínezDepartment of Biology, University of Puerto Rico- Río Piedras Campus, San Juan, PR 00931.
Jean L Messon-BirdDepartment of Biology, University of Puerto Rico- Río Piedras Campus, San Juan, PR 00931.ORCID 0009-0000-3276-1902
Diego A Pomales-MatosDepartment of Biology, University of Puerto Rico- Río Piedras Campus, San Juan, PR 00931.
Oswaldo L Echevarría-BonillaDepartment of Biology, University of Puerto Rico- Río Piedras Campus, San Juan, PR 00931.
Leandro Sanabria-AlbertoDepartment of Biology, University of Puerto Rico- Río Piedras Campus, San Juan, PR 00931.
Esther A Peterson-PegueroDepartment of Biology, University of Puerto Rico- Río Piedras Campus, San Juan, PR 00931.
José A Rodríguez-MartínezDepartment of Biology, University of Puerto Rico- Río Piedras Campus, San Juan, PR 00931.ORCID 0000-0002-1191-2887

Funding

SCIENCE AND TECHNOLOGY COMPETENCY & EDUCATION CORE (STCE)P20GM103475 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Jose R. Rodriguez-Medina · 2012 to 2026
$52.9M
Upgrade Laboratories Facilities at UPR-Rio PiedrasR25GM061151 · NIGMS · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI CARBALLEIRA, NESTOR MANUEL · 2001 to 2023
$32.5M
Increasing Diversity in Genomics for the Next generation (IDGeNe)R25HG012702 · NHGRI · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI JOSE E GARCIA-ARRARAS · 2022 to 2026
$1.7M
Uncovering the DNA recognition rules of cardiac transcription factorsSC1GM127231 · NIGMS · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI RODRIGUEZ-MARTINEZ, JOSE A · 2018 to 2021
$1.4M
U-RISE at University of Puerto Rico at CayeyT34GM145404 · NIGMS · UNIVERSITY OF PR CAYEY UNIVERSITY COLL · PI RESTO, WILFREDO, ROQUE, JOAN · 2023 to 2024
$808k
NHGRI NIH HHS R25 HG012702NIGMS NIH HHS P20 GM103475NIGMS NIH HHS R25 GM061151NIGMS NIH HHS SC1 GM127231NIGMS NIH HHS T34 GM145404
6 · The paper itself

Abstract

Missense mutations can alter the biochemical properties of proteins, including stability, structure, and function, potentially contributing to the development of multiple human diseases. Mutations in

Indexed as

DNA-binding affinitymissense mutationsTBX5thermal stabilityTranscription factor

Identifiers

PMID40463096
PMCPMC12132455

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.