Evidence map›Paper›PMID 40463071›Full record

ArticlebioRxiv : the preprint server for biology2025

Native-like soluble E1E2 glycoprotein heterodimers on self-assembling protein nanoparticles for hepatitis C virus vaccine design.

Linling He, Yi-Zong Lee, Yi-Nan Zhang, Maddy L Newby, Benjamin M Janus, Fabrizio G Gonzalez, Garrett Ward, Connor DesRoberts, Shr-Hau Hung, Erick Giang and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Linling HeDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Yi-Zong LeeDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Yi-Nan ZhangDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Maddy L NewbySchool of Biological Sciences, Highfield Campus, University of Southampton, Southampton, SO17 1BJ, UK.
Benjamin M JanusDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, 20742, USA.
Fabrizio G GonzalezDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, 20742, USA.
Garrett WardDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Connor DesRobertsDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Shr-Hau HungDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Erick GiangDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Joel D AllenSchool of Biological Sciences, Highfield Campus, University of Southampton, Southampton, SO17 1BJ, UK.ORCID 0000-0003-2547-968X
Liudmila KulakovaDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, 20742, USA.
Eric A TothDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, 20742, USA.
Thomas R FuerstDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, 20742, USA.
Mansun LawDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Gilad OfekDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, 20742, USA.
Max CrispinSchool of Biological Sciences, Highfield Campus, University of Southampton, Southampton, SO17 1BJ, UK.ORCID 0000-0002-1072-2694
Jiang ZhuDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
Novel HCV vaccine antigens and nanoparticlesP01AI168251 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI Mansun Law · 2022 to 2026
$12.6M
Understanding human antibody responses to chronic viral hepatitis CR01AI168917 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI Mansun Law · 2022 to 2026
$3.1M
NCI NIH HHS 75N91019D00024NIAID NIH HHS P01 AI168251NIAID NIH HHS R01 AI168917
6 · The paper itself

Abstract

Hepatitis C virus (HCV) is a leading cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma worldwide. E1E2-based HCV vaccine development has been hindered by the challenge of producing a soluble E1E2 (sE1E2) antigen that faithfully recapitulates the native glycoprotein heterodimer found on virions. Based on available cryo-electron microscopy (cryo-EM) structures, we rationally engineered sE1E2 for genotype 1a H77 by truncating the E1 and E2 stems (Cut

Identifiers

PMID40463071
PMCPMC12132513

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.