Evidence map›Paper›PMID 40463069›Full record

ArticlebioRxiv : the preprint server for biology2025

Tet1 safeguards lineage allocation in intestinal stem cells.

Antoine Gleizes, Nicolas V Janto, Sergei Bombin, Vivek Rao, Gurel Ari, Siyang Sun, Maria Fonseca, Adam D Gracz

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Antoine GleizesDepartment of Medicine, Division of Digestive Diseases, Emory University. Atlanta, GA USA.ORCID 0009-0002-5490-7743
Nicolas V JantoDepartment of Medicine, Division of Digestive Diseases, Emory University. Atlanta, GA USA.ORCID 0000-0003-3717-2220
Sergei BombinDepartment of Medicine, Division of Digestive Diseases, Emory University. Atlanta, GA USA.ORCID 0000-0002-8333-932X
Vivek RaoDepartment of Medicine, Division of Digestive Diseases, Emory University. Atlanta, GA USA.
Gurel AriDepartment of Medicine, Division of Digestive Diseases, Emory University. Atlanta, GA USA.ORCID 0000-0002-0964-4019
Siyang SunDepartment of Medicine, Division of Digestive Diseases, Emory University. Atlanta, GA USA.ORCID 0009-0001-2490-4288
Maria FonsecaDepartment of Biology, University of North Carolina at Chapel Hill. Chapel Hill, NC USA.
Adam D GraczDepartment of Medicine, Division of Digestive Diseases, Emory University. Atlanta, GA USA.ORCID 0000-0003-1298-568X

Funding

Winship Cancer Institute Cancer Center Support GrantP30CA138292 · NCI · EMORY UNIVERSITY · PI Ragini Reiney Kudchadkar · 2009 to 2026
$47.5M
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008490 · NIGMS · EMORY UNIVERSITY · PI BOSS, JEREMY M. · 1993 to 2022
$8.0M
Regulation of intestinal stem cell state by ID3R35GM142503 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Adam David Gracz · 2021 to 2026
$2.5M
Cleared Tissue Large FOV Microscope RequestS10OD032320 · OD · EMORY UNIVERSITY · PI MARCUS, ADAM I. · 2022 to 2022
$308k
Determining the role of Tet1 in facultative intestinal stem cellsF31DK136254 · NIDDK · EMORY UNIVERSITY · PI JANTO, NICOLAS VAUGHAN · 2023 to 2025
$146k
NCI NIH HHS P30 CA138292NIDDK NIH HHS F31 DK136254NIGMS NIH HHS R35 GM142503NIGMS NIH HHS T32 GM008490NIH HHS S10 OD032320
6 · The paper itself

Abstract

Intestinal stem cells (ISCs) balance self-renewal and differentiation to maintain the intestinal epithelial barrier, which is replaced weekly throughout adult life. Genetic control of ISC differentiation is well-defined relative to transcription factor (TF) activity, but less is known regarding the role of chromatin regulation in ISC biology. Prior work from our lab and others has shown that

Identifiers

PMID40463069
PMCPMC12132316

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.