Evidence map›Paper›PMID 40463062›Full record

ArticlebioRxiv : the preprint server for biology2025

The distribution of fitness effects varies phylogenetically across animals.

Meixi Lin, Sneha Chakraborty, Carlos Eduardo G Amorim, Sergio F Nigenda-Morales, Annabel C Beichman, Paulina G Nuñez-Valencia, Jonathan Mah, Jacqueline A Robinson, Christopher C Kyriazis, Christian D Huber and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Meixi LinDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, California, 90095, USA.ORCID 0000-0001-5233-0675
Sneha ChakrabortyDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, California, 90095, USA.
Carlos Eduardo G AmorimBiology Department, California State University, Northridge, California, 91330, USA.ORCID 0000-0002-8827-238X
Sergio F Nigenda-MoralesAdvanced Genomics Unit, National Laboratory of Genomics for Biodiversity (Langebio), Center for Research and Advanced Studies (Cinvestav), Irapuato, Guanajuato, 36824, Mexico.ORCID 0000-0002-2301-6975
Annabel C BeichmanDepartment of Genome Sciences, University of Washington, Seattle, Washington, 98195, USA.ORCID 0000-0002-6991-587X
Paulina G Nuñez-ValenciaAdvanced Genomics Unit, National Laboratory of Genomics for Biodiversity (Langebio), Center for Research and Advanced Studies (Cinvestav), Irapuato, Guanajuato, 36824, Mexico.ORCID 0000-0002-9742-5376
Jonathan MahBioinformatics Interdepartmental Program, University of California, Los Angeles, Los Angeles, California, 90095, USA.ORCID 0000-0003-3027-3141
Jacqueline A RobinsonInstitute for Human Genetics, University of California, San Francisco (UCSF), San Francisco, California, 94143, USA.ORCID 0000-0002-5556-815X
Christopher C KyriazisDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, California, 90095, USA.ORCID 0000-0002-8771-3681
Christian D HuberDepartment of Biology, Pennsylvania State University, University Park, Pennsylvania, 16802, USA.ORCID 0000-0002-2267-2604
Andrew E WebbDept. of Ecology and Evolutionary Biology, Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, 08544, USA.ORCID 0000-0001-9632-5560
Sarah D KocherDept. of Ecology and Evolutionary Biology, Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, 08544, USA.ORCID 0000-0001-5586-0727
Frederick I ArcherMarine Mammal and Turtle Division, Southwest Fisheries Science Center, La Jolla, California, 92037, USA.ORCID 0000-0002-3179-4769
Andrés Moreno-EstradaAdvanced Genomics Unit, National Laboratory of Genomics for Biodiversity (Langebio), Center for Research and Advanced Studies (Cinvestav), Irapuato, Guanajuato, 36824, Mexico.ORCID 0000-0001-8329-8292
Robert K WayneDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, California, 90095, USA.ORCID 0000-0002-9935-4719
Kirk E LohmuellerDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, California, 90095, USA.ORCID 0000-0002-3874-369X

Funding

Biological Mechanisms of Healthy Aging Training GrantT32AG066574 · NIA · UNIVERSITY OF WASHINGTON · PI David J. Marcinek, Jessica E Young · 2020 to 2026
$5.3M
Population genomics of the selective effects of new mutationsR35GM119856 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LOHMUELLER, KIRK · 2016 to 2025
$3.4M
Characterizing Human-Pathogen Interactions and Natural Selection with Ancient DNAR35GM142939 · NIGMS · CALIFORNIA STATE UNIVERSITY NORTHRIDGE · PI GUERRA AMORIM, CARLOS EDUARDO · 2021 to 2025
$1.8M
NIA NIH HHS T32 AG066574NIGMS NIH HHS R35 GM119856NIGMS NIH HHS R35 GM142939
6 · The paper itself

Abstract

The distribution of fitness effects (DFE) describes the selection coefficients (

Indexed as

deleterious variationsdistribution of selection coefficientseffective population sizeFisher’s geometric modelorganismal complexity

Identifiers

PMID40463062
PMCPMC12132501

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.