Evidence map›Paper›PMID 40463058›Full record

ArticlebioRxiv : the preprint server for biology2025

Chromatin Dynamics are Highly Subdiffusive Across Seven Orders of Magnitude.

Matteo Mazzocca, Domenic N Narducci, Simon Grosse-Holz, Jessica Matthias, Anders S Hansen

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Matteo MazzoccaDepartment of Biological Engineering, Massachusetts Institute of Technology; Cambridge, MA 02139, USA.ORCID 0000-0003-2079-1535
Domenic N NarducciDepartment of Biological Engineering, Massachusetts Institute of Technology; Cambridge, MA 02139, USA.ORCID 0000-0002-3453-7514
Simon Grosse-HolzCenter for Systems Biology Dresden, Pfotenhauerstraße 108, 01307 Dresden, Germany.ORCID 0000-0002-0717-5757
Jessica MatthiasAbberior Instruments America, Bethesda, MD 20814, USA.ORCID 0000-0001-6560-2174
Anders S HansenDepartment of Biological Engineering, Massachusetts Institute of Technology; Cambridge, MA 02139, USA.ORCID 0000-0001-7540-7858

Funding

Center for 3D Structure and Physics of the GenomeUM1HG011536 · NHGRI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DEKKER, JOB, MIRNY, LEONID A · 2020 to 2024
$11.8M
Resolving transcription factor target search mechanismsR01CA300848 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Anders Sejr Hansen · 2024 to 2026
$2.9M
DYNAMIC BOTTOM-UP DISSECTION OF CHROMATIN LOOPING AND GENE REGULATIONDP2GM140938 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HANSEN, ANDERS SEJR · 2020 to 2020
$2.3M
An integrated toolkit for real-time analysis of coupled nascent transcriptionR01EB035127 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Anders Sejr Hansen · 2024 to 2026
$1.3M
Super-resolution microscopy for dynamic analysis of focal enhancer amplifications in cancerR33CA257878 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HANSEN, ANDERS SEJR · 2021 to 2023
$1.1M
Ultra-high resolution 3D genome maps for multiple human tissuesR03OD038390 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HANSEN, ANDERS SEJR, LIU, JIE · 2024 to 2024
$309k
NCI NIH HHS R01 CA300848NCI NIH HHS R33 CA257878NHGRI NIH HHS UM1 HG011536NIBIB NIH HHS R01 EB035127NIGMS NIH HHS DP2 GM140938NIH HHS R03 OD038390
6 · The paper itself

Abstract

Chromatin dynamics control the timescales of essential biological processes including DNA damage repair and activation of gene promoters by distal enhancers. Prior chromatin dynamics studies have reported widely varying degrees of subdiffusion, likely due to technical limitations. Here, we integrate MINFLUX-a recently developed single particle tracking method capable of achieving microsecond time resolution-with traditional tracking methodologies. We tracked chromatin dynamics across seven orders of magnitude in time in both human and mouse cells and found strongly subdiffusive dynamics (

Indexed as

Chromatin dynamicsFirst passage timesLive-cell ImagingMINFLUXSPT

Identifiers

PMID40463058
PMCPMC12132355

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.