Evidence map›Paper›PMID 40463052›Full record

ArticlebioRxiv : the preprint server for biology2025

Alcohol Use Disorder Associated Gene

Xiujuan Zhu, August J John, Li Wang, Sooan Kim, Enci Ding, Ateka Saleh, Irene Marín-Goñi, Abedalrahman Jomaa, Huanyao Gao, Ching Man Wai and 11 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Xiujuan ZhuDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN. U.S.A.
August J JohnDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN. U.S.A.
Li WangDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN. U.S.A.
Sooan KimDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN. U.S.A.
Enci DingDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN. U.S.A.
Ateka SalehDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN. U.S.A.
Irene Marín-GoñiDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN. U.S.A.
Abedalrahman JomaaDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN. U.S.A.
Huanyao GaoDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN. U.S.A.
Ching Man WaiDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Irene MoonDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN. U.S.A.
Brandon J CoombesDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, U.S.A.
Tony M KerrDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN. U.S.A.
Nobuyoshi SutoDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN. U.S.A.ORCID 0000-0002-8994-2592
Liewei WangDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN. U.S.A.
Mark A FryeDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, U.S.A.ORCID 0000-0001-6997-4215
Joanna M BiernackaDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, U.S.A.ORCID 0000-0001-9350-4440
Victor M KarpyakDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, U.S.A.ORCID 0000-0002-9552-6130
Hu LiDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN. U.S.A.ORCID 0000-0001-5957-5472
Richard M WeinshilboumDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN. U.S.A.ORCID 0000-0002-4911-7985
Duan LiuDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN. U.S.A.ORCID 0000-0003-1065-246X

Funding

TRAINING GRANT IN CLINICAL PHARMACOLOGYT32GM008685 · NIGMS · MAYO CLINIC ROCHESTER · PI Liewei Wang · 1998 to 2026
$8.2M
INHERITED VARIATIONS IN DRUG-METABOLIZING ENZYMESR01GM028157 · NIGMS · MAYO CLINIC ROCHESTER · PI WEINSHILBOUM, RICHARD M. · 1985 to 2019
$6.9M
Alcohol Use Disorder: Acamprosate Pharmacometabolomics-informed PharmacogenomicsR01AA027486 · NIAAA · MAYO CLINIC ROCHESTER · PI Ming-Fen Ho, Richard M. Weinshilboum · 2018 to 2026
$4.0M
NIAAA NIH HHS R01 AA027486NIGMS NIH HHS R01 GM028157NIGMS NIH HHS T32 GM008685
6 · The paper itself

Abstract

Large-cohort genome-wide association studies (GWAS) for alcohol use disorder (AUD) and AUD-related phenotypes have identified more than one hundred genetic loci. Functional study of those GWAS-identified loci might represent an important step toward understanding AUD pathophysiology. We found that genetic loci which are splicing quantitative trait loci (sQTLs) for the

Identifiers

PMID40463052
PMCPMC12132278

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.