Evidence map›Paper›PMID 40463049›Full record

ArticlebioRxiv : the preprint server for biology2025

A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain.

Mera F Liccione, Trevor Scobey, Heather M Froggatt, Camryn Pajon, Boyd L Yount, Qi Yin, Taylor N Spence, Emmanuel B Walter, Kevin O Saunders, Robert J Edwards and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Mera F LiccioneDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Trevor ScobeyDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Heather M FroggattDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Camryn PajonDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Boyd L YountDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Qi YinDuke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA.
Taylor N SpenceDuke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA.
Emmanuel B WalterDuke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA.
Kevin O SaundersDuke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0001-7399-7954
Robert J EdwardsDuke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA.
Ralph S BaricDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0001-6827-8701
Barton F HaynesDuke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA.
Derek W CainDuke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0002-5988-6729
Timothy P SheahanDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0001-9181-2183
Daniel WrappDuke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0002-0538-9647

Funding

Project 4: Computational panbetaCoV immunogen designP01AI158571 · NIAID · DUKE UNIVERSITY · PI HAYNES, BARTON F. · 2021 to 2023
$28.0M
Regional Biocontainment Laboratory (RBL)UC6AI058607 · NIAID · DUKE UNIVERSITY · PI WILLIAMS, R SANDERS · 2003 to 2005
$16.3M
NIAID NIH HHS P01 AI158571NIAID NIH HHS UC6 AI058607
6 · The paper itself

Abstract

HCoV-229E is an endemic

Indexed as

APNcoronaviruscryo-EMHCoV-229Eneutralizing mAbprefusion SRBD

Identifiers

PMID40463049
PMCPMC12132451

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.