Evidence map›Paper›PMID 40463041›Full record

ArticlebioRxiv : the preprint server for biology2025

Impact of maternal compensation on developmental phenotypes in a zebrafish model of severe congenital muscular dystrophy.

Kyle P Flannery, Shorbon Mowla, Namarata Battula, L Rose Clark, Deze Liu, Callista D Oliveira, Cynthia Venkatesan, Lillian M Simhon, Brittany F Karas, Kristin R Terez and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Kyle P FlanneryDepartment of Neuroscience and Cell Biology, Rutgers-Robert Wood Johnson Medical School, Child Health Institute of New Jersey, New Brunswick, NJ 08901.
Shorbon MowlaDepartment of Neuroscience and Cell Biology, Rutgers-Robert Wood Johnson Medical School, Child Health Institute of New Jersey, New Brunswick, NJ 08901.
Namarata BattulaDepartment of Neuroscience and Cell Biology, Rutgers-Robert Wood Johnson Medical School, Child Health Institute of New Jersey, New Brunswick, NJ 08901.
L Rose ClarkDepartment of Neuroscience and Cell Biology, Rutgers-Robert Wood Johnson Medical School, Child Health Institute of New Jersey, New Brunswick, NJ 08901.
Deze LiuDepartment of Electrical and Computer Engineering, Rutgers University, Piscataway, NJ 08854.
Callista D OliveiraDepartment of Neuroscience and Cell Biology, Rutgers-Robert Wood Johnson Medical School, Child Health Institute of New Jersey, New Brunswick, NJ 08901.
Cynthia VenkatesanDepartment of Neuroscience and Cell Biology, Rutgers-Robert Wood Johnson Medical School, Child Health Institute of New Jersey, New Brunswick, NJ 08901.
Lillian M SimhonDepartment of Neuroscience and Cell Biology, Rutgers-Robert Wood Johnson Medical School, Child Health Institute of New Jersey, New Brunswick, NJ 08901.
Brittany F KarasDepartment of Neuroscience and Cell Biology, Rutgers-Robert Wood Johnson Medical School, Child Health Institute of New Jersey, New Brunswick, NJ 08901.
Kristin R TerezDepartment of Neuroscience and Cell Biology, Rutgers-Robert Wood Johnson Medical School, Child Health Institute of New Jersey, New Brunswick, NJ 08901.
Daniel Burbano-LombanaDepartment of Electrical and Computer Engineering, Rutgers University, Piscataway, NJ 08854.
M Chiara ManziniDepartment of Neuroscience and Cell Biology, Rutgers-Robert Wood Johnson Medical School, Child Health Institute of New Jersey, New Brunswick, NJ 08901.

Funding

Identification of Genetic and Molecular Pathways in Congenital Rare Disorders Affecting the Brain and MuscleR01NS109149 · NINDS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI MANZINI, M. CHIARA · 2019 to 2023
$1.7M
NINDS NIH HHS R01 NS109149
6 · The paper itself

Abstract

Genetic compensation is a common phenomenon in zebrafish in response to genetic alterations. As such, differences between morphant and mutant zebrafish models of human diseases have led to significant difficulties in phenotypic interpretation and translatability. One form of compensation is the maternal deposit of mRNAs and proteins into the oocyte that supports developmental processes before zygotic genome activation. In this study, we generated a zebrafish model of severe congenital muscular dystrophy by targeting

Identifiers

PMID40463041
PMCPMC12132350

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.