ArticlebioRxiv : the preprint server for biology2025
Monte Carlo track-structure simulation of the impact of Ultra-Hight Dose Rate and oxygen concentration on the Fenton reaction.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Preclinical investigations studies have shown that FLASH radiotherapy (FLASH-RT), delivering radiation in ultra-high dose rates (UHDR), preserves healthy tissue and reduces toxicity, all while maintaining an effective tumor response compared to conventional radiotherapy (CONV-RT), the combined biological benefit was termed as "FLASH effect". However, the mechanisms responsible for this effect remain unclear. Research demonstrated that oxygen concentration contributes to the FLASH effect, and it has been hypothesized that Fenton reaction might play a role in the "FLASH effect". Purpose: We propose to investigate the effect of ultra-high dose rate (UHDR), compared to conventional dose rates (CONV), on the Fenton reaction by studying the radiolysis of Fricke solution. The study will focus on how dose, dose rate, and initial oxygen concentration influence the activation of the Fenton reaction. Methods and Materials: TOPAS-nBio version 2.0 was used to simulate the radiolysis of the Fricke system. A cubic water phantom of 3μm side was irradiated by 300MeV protons on one of its edges. For UHDR, a proton field (1.5×1.5μm Results: For CONV, G(Fe Conclusions: UHDR reduces the yield of Fe
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