Evidence map›Paper›PMID 40462995›Full record

ArticlebioRxiv : the preprint server for biology2025

Direct interoceptive input to the insular cortex shapes learned feeding behavior.

Zhe Zhao, Binbin Xu, Skylar Anthony, Suganya Subramanian, Bryan Granger, Carolyn Von-Walter, Elisa Mizrachi, Matthew Kidd, Abhishikta Srigiriraju, Isaac McKie and 4 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zhe ZhaoMax Planck Florida Institute for Neuroscience, Jupiter, FL 33458, USA.
Binbin XuEuroMov Digital Health in Motion, Univ Montpellier, IMT Mines Alès, 6 Av. de Clavières, 30100 Alès, France.
Skylar AnthonyMax Planck Florida Institute for Neuroscience, Jupiter, FL 33458, USA.
Suganya SubramanianMedical University of South Carolina, Charleston, SC 29425, USA.
Bryan GrangerMedical University of South Carolina, Charleston, SC 29425, USA.
Carolyn Von-WalterMax Planck Florida Institute for Neuroscience, Jupiter, FL 33458, USA.
Elisa MizrachiMax Planck Florida Institute for Neuroscience, Jupiter, FL 33458, USA.
Matthew KiddInternational Max Planck Research School for Synapses and Circuits, Jupiter, FL 33458, USA.
Abhishikta SrigirirajuMax Planck Florida Institute for Neuroscience, Jupiter, FL 33458, USA.
Isaac McKieMax Planck Florida Institute for Neuroscience, Jupiter, FL 33458, USA.
Zhiying LiThe Rockefeller University, New York, NY 10065, USA.
M McLean BoltonMax Planck Florida Institute for Neuroscience, Jupiter, FL 33458, USA.
Stefano BertoMedical University of South Carolina, Charleston, SC 29425, USA.
Sarah A SternMax Planck Florida Institute for Neuroscience, Jupiter, FL 33458, USA.

Funding

The Role of Early Life Stress in Feeding BehaviorsP20GM148302 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Jose H Ledo · 2023 to 2026
$11.5M
Identifying neurons for interoception using simultaneous profiling of activity- and projection- specific populationsDP2DA060436 · NIDA · MAX PLANCK FLORIDA CORPORATION · PI Sarah Stern · 2023 to 2026
$2.9M
NIDA NIH HHS DP2 DA060436NIGMS NIH HHS P20 GM148302
6 · The paper itself

Abstract

The insular cortex (insula) is an interoceptive hub, which senses internal states such as hunger, thirst, pain, and emotions. Previous studies suggest that the insula directly senses internal states, but the mechanisms remain elusive. We identified a population of leptin receptor-positive cells with a unique morphology in the insula (INS

Indexed as

body weightcalcium imagingfeedinginsular cortexinteroceptionleptinoperant behavioroptogeneticstranscriptomics

Identifiers

PMID40462995
PMCPMC12132522

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.