Evidence map›Paper›PMID 40462974›Full record

ArticlebioRxiv : the preprint server for biology2025

Deep homology and design of proteasome chaperone proteins in

Jackson R Rapala, Mohammad Siddiq, Patricia J Wittkopp, Matthew J O'Meara, Teresa R O'Meara

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Jackson R RapalaDepartment of Microbiology and Immunology, University of Michigan Medical School; Ann Arbor MI 48019 USA.ORCID 0000-0003-0501-4615
Mohammad SiddiqDepartment of Ecology and Evolutionary Biology, University of Michigan; Ann Arbor MI 48019 USA.ORCID 0000-0002-9186-1978
Patricia J WittkoppDepartment of Ecology and Evolutionary Biology, University of Michigan; Ann Arbor MI 48019 USA.ORCID 0000-0001-7619-0048
Matthew J O'MearaGilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan Medical School; Ann Arbor MI 48019 USA.
Teresa R O'MearaDepartment of Microbiology and Immunology, University of Michigan Medical School; Ann Arbor MI 48019 USA.ORCID 0000-0002-8901-0154

Funding

The Michigan Infectious Disease Genomics (MIDGE) CenterU19AI181767 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LAURING, ADAM, SNITKIN, EVAN · 2024 to 2024
$6.2M
Genetic mechanisms and evolutionary processes underlying diversity within and between speciesR35GM118073 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WITTKOPP, PATRICIA JEAN · 2016 to 2025
$4.1M
Michigan Predoctoral Training in GeneticsT32GM149391 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JOHN V. MORAN · 2024 to 2026
$2.2M
Discovery of gene function and dissection of network re-wiring in non-model fungiR35GM147894 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Teresa R. OMeara · 2022 to 2026
$2.0M
Learning How to Give Casual Explanations for Large Scale Virtual and Morphological PharmacologyR35GM151129 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Matthew J O'Meara · 2023 to 2026
$1.5M
Genetic mechanisms and coevolutionary interactions in the evolution of gene expression divergenceF32CA261115 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SIDDIQ, MOHAMMAD · 2021 to 2023
$210k
NCI NIH HHS F32 CA261115NIAID NIH HHS U19 AI181767NIGMS NIH HHS R35 GM118073NIGMS NIH HHS R35 GM147894NIGMS NIH HHS R35 GM151129NIGMS NIH HHS T32 GM149391
6 · The paper itself

Abstract

A central tenet of biology is that protein structure mediates the sequence-function relationship. Recently, there has been excitement about the promise of advances in protein structure modeling to generate hypotheses about sequence-structure-function relationships based on successes with controlled benchmarks. Here, we leverage structural similarity to identify rapidly evolving proteasome assembly chaperones and characterize their function in the emerging fungal pathogen

Identifiers

PMID40462974
PMCPMC12132334

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.