Evidence map›Paper›PMID 40462973›Full record

ArticlebioRxiv : the preprint server for biology2025

Prolonged non-suppressible viremia sustained by a clonally expanded, genomically defective provirus with an immune-evasive HIV protein expression profile.

F Harrison Omondi, Yurou Sang, Francis Mwimanzi, Peter K Cheung, Zerufael Derza, Winnie Dong, Evan Barad, Kieran Anderson, Vitaliy Mysak, Viviane D Lima and 7 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

F Harrison OmondiFaculty of Health Sciences, Simon Fraser University, Burnaby, Canada.ORCID 0000-0003-0940-7512
Yurou SangFaculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
Francis MwimanziFaculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
Peter K CheungFaculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
Zerufael DerzaFaculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
Winnie DongBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Evan BaradFaculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
Kieran AndersonDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, Canada.
Vitaliy MysakBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Viviane D LimaBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Mark HullDepartment of Medicine, University of British Columbia, Vancouver, Canada.
Chanson J BrummeBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Marianne HarrisBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Julio S G MontanerBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Silvia GuillemiBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Mark A BrockmanFaculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
Zabrina L BrummeFaculty of Health Sciences, Simon Fraser University, Burnaby, Canada.

Funding

REACH: Research Enterprise to Advance a Cure for HIVUM1AI164565 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Marina Caskey, R. Brad Jones · 2021 to 2026
$32.9M
NIAID NIH HHS UM1 AI164565Wellcome Trust
6 · The paper itself

Abstract

Antiretroviral therapy (ART) potently inhibits HIV replication but does not eliminate HIV proviruses integrated within the genomes of infected cells. Though ART normally suppresses HIV to clinically undetectable levels in blood, some individuals experience non-suppressible viremia (NSV) that is not attributable to suboptimal drug exposure (

Identifiers

PMID40462973
PMCPMC12132533

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.