Evidence map›Paper›PMID 40462969›Full record

ArticlebioRxiv : the preprint server for biology2025

Click chemistry-based quantification of extracellular matrix turnover for drug screening and regenerative medicine.

Annie Porter, Songshan Fan, Ying Peng, Mengxi Lv, Yilu Zhou, Abdulaziz Alanazi, Lin Han, Liyun Wang, X Lucas Lu

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Annie PorterDepartment of Mechanical Engineering, University of Delaware, Newark, Delaware, 19716, USA.ORCID 0000-0002-8207-0357
Songshan FanDepartment of Mechanical Engineering, University of Delaware, Newark, Delaware, 19716, USA.
Ying PengDepartment of Mechanical Engineering, University of Delaware, Newark, Delaware, 19716, USA.
Mengxi LvDepartment of Mechanical Engineering, University of Delaware, Newark, Delaware, 19716, USA.
Yilu ZhouDepartment of Mechanical Engineering, University of Delaware, Newark, Delaware, 19716, USA.
Abdulaziz AlanaziSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA.
Lin HanSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA.ORCID 0000-0003-4180-1288
Liyun WangDepartment of Mechanical Engineering, University of Delaware, Newark, Delaware, 19716, USA.
X Lucas LuDepartment of Mechanical Engineering, University of Delaware, Newark, Delaware, 19716, USA.

Funding

Understanding synovial macrophage inflamm-aging within osteoarthritisP20GM139760 · NIGMS · UNIVERSITY OF DELAWARE · PI DAWN M ELLIOTT · 2021 to 2026
$19.1M
Biomechanics of Cartilage: Roles of Decorin in ECM Assembly and DegradationR01AR074490 · NIAMS · DREXEL UNIVERSITY · PI Lin Han · 2019 to 2026
$2.3M
Prevention of PTOA via regulation of the cytomechanics of chondrocytesR01AR074472 · NIAMS · UNIVERSITY OF DELAWARE · PI LU, X. LUCAS · 2020 to 2025
$1.5M
NIAMS NIH HHS R01 AR074472NIAMS NIH HHS R01 AR074490NIGMS NIH HHS P20 GM139760
6 · The paper itself

Abstract

This study presents a sensitive and cost-efficient method to quantify extracellular matrix (ECM) synthesis and degradation using copper-free click chemistry reactions to fluorescently label new ECM components. The approach enables spatial visualization and longitudinal measurement of specific ECM turnover

Indexed as

CartilageClick ChemistryCollagenGlycosaminoglycanMetabolic labelingTissue engineering

Identifiers

PMID40462969
PMCPMC12132353

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.