Evidence map›Paper›PMID 40462939›Full record

ArticlebioRxiv : the preprint server for biology2025

A close unicellular relative reveals aggregative multicellularity was key to the evolution of animals.

Ruibao Li, Jennah E Dharamshi, Kyle Kwok, Iñaki Ruiz-Trillo, Joseph P Gerdt

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ruibao LiDepartment of Chemistry, Indiana University Bloomington, Indiana, USA.
Jennah E DharamshiDepartment of Organismal Biology, Systematic Biology, Uppsala University, Uppsala, Sweden.
Kyle KwokDepartment of Chemistry, Indiana University Bloomington, Indiana, USA.
Iñaki Ruiz-TrilloInstitut de Biologia Evolutiva (CSIC-Universitat Pompeu Fabra), Barcelona, Spain.
Joseph P GerdtDepartment of Chemistry, Indiana University Bloomington, Indiana, USA.ORCID 0000-0002-0375-4110

Funding

Elucidation of the first interspecies chemical signaling mechanisms in Capsaspora owczarzaki--the predator of a human pathogen and a model for the evolution of animal multicellularityR35GM138376 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI Joseph P. Gerdt · 2020 to 2026
$3.0M
NIGMS NIH HHS R35 GM138376
6 · The paper itself

Abstract

How animals evolved complex multicellularity from their unicellular ancestors remains unanswered. Unicellular relatives of animals exhibit simple multicellularity through clonal division, formation of multinucleate coenocytes, or aggregation.

Indexed as

Aggregationanimal originsevolutionary transitionsmulticellularityunicellular Holozoa

Identifiers

PMID40462939
PMCPMC12132279

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.