Evidence map›Paper›PMID 40462935›Full record

ArticlebioRxiv : the preprint server for biology2025

Unusually Broad-spectrum small-molecule sensing using a single protein scaffold.

H Tian, J Beltrán, W George, C Lenert-Mondou, N Seder, Z I Davis, S D Swift, T Girke, T A Whitehead, I Wheeldon and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

H TianBotany and Plant Sciences, University of California, Riverside, Riverside, CA 92521.
J BeltránBotany and Plant Sciences, University of California, Riverside, Riverside, CA 92521.
W GeorgeBotany and Plant Sciences, University of California, Riverside, Riverside, CA 92521.
C Lenert-MondouBiochemistry and Molecular Biology, University of California, Riverside, Riverside, CA 92521.
N SederBioengineering, University of California, Riverside, Riverside, CA 92521.
Z I DavisChemical and Biological Engineering, University of Colorado Boulder; Boulder, 80305.
S D SwiftChemical and Biological Engineering, University of Colorado Boulder; Boulder, 80305.
T GirkeBotany and Plant Sciences, University of California, Riverside, Riverside, CA 92521.
T A WhiteheadChemical and Biological Engineering, University of Colorado Boulder; Boulder, 80305.
I WheeldonChemical and Environmental Engineering, University of California, Riverside, Riverside, CA 92507.
S R CutlerBotany and Plant Sciences, University of California, Riverside, Riverside, CA 92521.

Funding

Diagnostics on demand: a biosensor platform for multiplexed small molecule detectionR01GM151616 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Sean Cutler · 2023 to 2026
$1.7M
NIGMS NIH HHS R01 GM151616
6 · The paper itself

Abstract

Small-molecule sensing in plants is dominated by chemical-induced dimerization modules. In the abscisic acid (ABA) system, allosteric receptors recruit phosphatase effectors and achieve nM

Identifiers

PMID40462935
PMCPMC12132232

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.