Evidence map›Paper›PMID 40462908›Full record

ArticlebioRxiv : the preprint server for biology2025

1-Deoxysphingolipids dysregulate membrane properties and cargo trafficking in the early secretory pathway.

Yi-Ting Tsai, Nicolas-Frédéric Lipp, Olivia Seidel, Riya Varma, Aurelie Laguerre, Kristina Solorio-Kirpichyan, Adrian Wong, Roberto J Brea, Grace H McGregor, Thekla Cordes and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Yi-Ting TsaiDepartment of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093.
Nicolas-Frédéric LippDepartment of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093.ORCID 0000-0001-7963-7415
Olivia SeidelDepartment of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093.
Riya VarmaDepartment of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093.
Aurelie LaguerreDepartment of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093.
Kristina Solorio-KirpichyanDepartment of Cell and Developmental Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093.
Adrian WongDepartment of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093.
Roberto J BreaDepartment of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093.
Grace H McGregorDepartment of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093.
Thekla CordesDepartment of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093.
Neal K DevarajDepartment of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093.
Lars KuerschnerLife & Medical Sciences Institute, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany.
Sonya NealDepartment of Cell and Developmental Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093.
Christian M MetalloDepartment of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093.ORCID 0000-0003-2404-3040
Itay BudinDepartment of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093.ORCID 0000-0001-9706-4294

Funding

Lipidic drivers of organelle function and dysregulationR35GM142960 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Itay Budin · 2021 to 2026
$4.3M
Molecular Biophysics Training Grant at UC San DiegoT32GM139795 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Galia Debelouchina, ELIZABETH A. KOMIVES · 2021 to 2026
$3.0M
The Discovery of Molecules and Mechanisms of the Rhomboid SuperfamilyR35GM133565 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Sonya Elina Neal · 2019 to 2026
$2.9M
Illuminating cellular dark matter through the development of novel chemical toolsR35GM141939 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEVARAJ, NEAL KRISHNA · 2021 to 2025
$2.2M
Non-essential amino acids and sphingolipid diversity in cancer progressionR01CA234245 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI METALLO, CHRISTIAN MICHAEL · 2019 to 2023
$1.9M
Chemistry-Biology Interfaces at UCSDT32GM146648 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Michael D. Burkart, Alexis C. Komor · 2022 to 2026
$876k
NCI NIH HHS R01 CA234245NIGMS NIH HHS R35 GM133565NIGMS NIH HHS R35 GM141939NIGMS NIH HHS R35 GM142960NIGMS NIH HHS T32 GM139795NIGMS NIH HHS T32 GM146648
6 · The paper itself

Abstract

1-Deoxysphingolipids are non-canonical sphingolipids linked to several diseases, but their cellular effects are poorly understood. Here, we utilize lipid chemical biology approaches to investigate the role of 1-deoxysphingolipid metabolism on the properties and functions of secretory membranes. We first applied organelle-specific bioorthogonal labeling to visualize the subcellular distribution of metabolically tagged 1-deoxysphingolipids in RPE-1 cells, observing that they are retained in the endoplasmic reticulum (ER). We found that 1-deoxysphingolipids can be transported by the non-vesicular transporter CERT

Identifiers

PMID40462908
PMCPMC12132412

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.