Evidence map›Paper›PMID 40462861›Full record

ArticleBrain communications2025

Differential tractography: an imaging marker for tissue degeneration in neurodegenerative diseases.

Connor J Lewis, Zeynep Vardar, Anna Luisa Kühn, Jean M Johnston, Precilla D'Souza, Muhammad H Yousef, William A Gahl, Mohammed Salman Shazeeb, Cynthia J Tifft, Maria T Acosta

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Diffusion tensor imaging in Chediak Higashi Disease.medRxiv : the preprint server for health sciences · 2025
    Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Connor J LewisOffice of the Clinical Director, National Human Genome Research Institute, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0002-8204-5848
Zeynep VardarDepartment of Radiology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.ORCID https://orcid.org/0000-0002-7510-9524
Anna Luisa KühnDepartment of Radiology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
Jean M JohnstonOffice of the Clinical Director, National Human Genome Research Institute, Bethesda, MD 20892, USA.
Precilla D'SouzaOffice of the Clinical Director, National Human Genome Research Institute, Bethesda, MD 20892, USA.
Muhammad H YousefDepartment of Perioperative Medicine, National Institutes of Health Clinical Center, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0003-0831-8462
William A GahlMedical Genetics Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA.
Mohammed Salman ShazeebDepartment of Radiology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
Cynthia J TifftOffice of the Clinical Director, National Human Genome Research Institute, Bethesda, MD 20892, USA.
Maria T AcostaOffice of the Clinical Director, National Human Genome Research Institute, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0001-8914-7401

Funding

Pathogenesis informs therapy in the GM1 and GM2 GangliosidosesZIAHG200409 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI TIFFT, CYNTHIA · 2020 to 2025
$4.1M
Intramural NIH HHS ZIA HG200409
6 · The paper itself

Abstract

GM1 gangliosidosis is an ultra-rare inherited neurodegenerative lysosomal storage disorder caused by biallelic mutations in the

Indexed as

differential tractographydiffusion tensor imagingGM1 gangliosidosismagnetic resonance imagingneuroimaging markers

Identifiers

PMID40462861
PMCPMC12130619

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.