ArticleAllergy2025
Gene-Environment Interaction Affects Risk of Atopic Eczema: Population and In Vitro Studies.
Erratum issuedAbstract read
In one paragraph
Article in Allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.
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0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Association of atopic multimorbidity with childhood pet exposure and caesarean section delivery: a retrospective study from the Lifelines Cohort Study.Skin health and disease · 2026Article
- Bridging Rare to Common Diseases: Precision Medicine and the Transforming Landscape of Pediatric Allergy and Immunology.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Review
- From preterm protection to post-term predisposition: gestational age and the allergy spectrum.Pediatric research · 2026Article
- Early Risk Assessment and Recognition of Allergies in Children: Rationale, Methodology, and Proposed Algorithms.Allergy · 2026Review
- The rs3024839 and rs2227483 polymorphisms with immune pathomechanism offers a starting point for diagnosis and susceptibility testing of myocardial infarction.Scientific reports · 2026Article
- An online program focusing on modifiable lifestyle and environmental interventions was associated with improved pediatric eczema symptoms: results from a retrospective observational study.Frontiers in allergy · 2026Article
Corrections and comments
- Erratum issued
- Update of
Authors and funding
78 authors.
Marie StandlInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.ORCID https://orcid.org/0000-0002-5345-2049
Ashley Budu-AggreyMRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK.ORCID https://orcid.org/0000-0002-8911-2492
Luke J JohnstonCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID https://orcid.org/0000-0001-9656-8896
Martina S EliasCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID https://orcid.org/0000-0003-3352-5391
S Hasan ArshadClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID https://orcid.org/0000-0001-5988-235X
Peter BagerDepartment of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-3577-8459
Veronique BatailleDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.ORCID https://orcid.org/0000-0002-8750-4150
Helena BlakewayMRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK.ORCID https://orcid.org/0000-0003-4000-8923
Klaus BønnelykkeCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0003-2003-1018
Dorret BoomsmaDepartment of Biological Psychology, Faculty of Behavioral and Movement Sciences, Vrije Universiteit, Amsterdam, the Netherlands.ORCID https://orcid.org/0000-0002-7099-7972
Ben M BrumptonDepartment of Public Health and Nursing, HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway.ORCID https://orcid.org/0000-0002-3058-1059
Mariona Bustamante PinedaISGlobal, Institute for Global Health, Barcelona, Spain.ORCID https://orcid.org/0000-0003-0127-2860
Archie CampbellCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID https://orcid.org/0000-0003-0198-5078
John A CurtinDivision of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, and Manchester University NHS Foundation Trust, Manchester, UK.ORCID https://orcid.org/0009-0008-6717-5960
Anders EliasenCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0003-2629-0790
João P S FadistaDepartment of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark.ORCID https://orcid.org/0000-0003-2539-634X
Bjarke FeenstraDepartment of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark.ORCID https://orcid.org/0000-0003-1478-649X
Trine GernerDepartment of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.ORCID https://orcid.org/0000-0002-5377-4013
Carolina Medina-GomezDepartment of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID https://orcid.org/0000-0001-7999-5538
Sarah GroscheMax-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany.ORCID https://orcid.org/0000-0002-7658-0932
Kristine B GutzkowDivision of Climate and Environmental Health, Department of Air Quality and Noise, Norwegian Institute of Public Health (NIPH), Oslo, Norway.ORCID https://orcid.org/0000-0002-6716-5921
Anne-Sofie HallingDepartment of Dermatology and Venereology, Bispebjerg Hospital, University of Copenhagen, Copenhagen N, Denmark.ORCID https://orcid.org/0000-0003-0166-6560
Caroline HaywardCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID https://orcid.org/0000-0002-9405-9550
John HendersonMRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK.
Esther Herrera-LuisDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0003-4150-5454
John W HollowayNIHR Southampton Biomedical Research Centre, University Hospitals Southampton NHS Foundation Trust, Southampton, UK.ORCID https://orcid.org/0000-0001-9998-0464
Joukejan HottengaDepartment of Biological Psychology, Faculty of Behavioral and Movement Sciences, Vrije Universiteit, Amsterdam, the Netherlands.ORCID https://orcid.org/0000-0002-5668-2368
Jonathan O'B HourihaneRoyal College of Surgeons in Ireland, Dublin, Ireland.ORCID https://orcid.org/0000-0003-4997-9857
Chen HuThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID https://orcid.org/0000-0002-9180-5781
Kristian HveemDepartment of Public Health and Nursing, HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway.ORCID https://orcid.org/0000-0001-8157-9744
Amaia IrizarSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.ORCID https://orcid.org/0000-0002-0377-7339
Bénédicte JacqueminUniv Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, France.ORCID https://orcid.org/0000-0003-1273-9892
Leon JessenCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0003-2879-2559
Sara KressIUF-Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.ORCID https://orcid.org/0009-0000-0313-7510
Ramesh J KurukulaaratchyClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID https://orcid.org/0000-0002-1588-2400
Susanne LauDepartment of Pediatric Respiratory Medicine, Immunology, and Intensive Care Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-5189-4265
Sabrina LlopSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.ORCID https://orcid.org/0000-0002-6784-4211
Mari LøsetDepartment of Public Health and Nursing, HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway.ORCID https://orcid.org/0000-0003-3736-6551
Ingo MarenholzMax-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany.
Dan MasonBradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK.ORCID https://orcid.org/0000-0002-0026-9216
Daniel L McCartneyCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID https://orcid.org/0000-0003-3242-0360
Mads MelbyeDanish Cancer Institute, Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-8264-6785
Erik MelénDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-8248-0663
Camelia MinicaDepartment of Biological Psychology, Faculty of Behavioral and Movement Sciences, Vrije Universiteit, Amsterdam, the Netherlands.ORCID https://orcid.org/0000-0001-7140-8167
Clare S MurrayDivision of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, and Manchester University NHS Foundation Trust, Manchester, UK.ORCID https://orcid.org/0000-0002-8961-8055
Tamar NijstenDepartment of Dermatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID https://orcid.org/0000-0001-9940-2875
Luba M PardoDepartment of Dermatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID https://orcid.org/0000-0003-0684-3175
Suzanne PasmansDepartment of Dermatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID https://orcid.org/0000-0003-1018-4475
Craig E PennellSchool of Medicine and Public Health, The University of Newcastle, Newcastle, New South Wales, Australia.ORCID https://orcid.org/0000-0002-0937-6165
Maria R RinnovDepartment of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.ORCID https://orcid.org/0000-0003-4624-6180
Gillian SantorelliBradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK.ORCID https://orcid.org/0000-0003-0427-1783
Tamara SchikowskiIUF-Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.ORCID https://orcid.org/0000-0001-7923-6259
Darina SheehanINFANT Centre, University College Cork, Cork, Ireland.
Angela SimpsonDivision of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, and Manchester University NHS Foundation Trust, Manchester, UK.ORCID https://orcid.org/0000-0003-2733-6666
Cilla SöderhällDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-8397-3080
Laurent F ThomasDepartment of Public Health and Nursing, HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway.ORCID https://orcid.org/0000-0003-0548-2486
Jacob P ThyssenDepartment of Dermatology and Venereology, Bispebjerg Hospital, University of Copenhagen, Copenhagen N, Denmark.ORCID https://orcid.org/0000-0003-3770-1743
Maties TorrentArea de Salut de Menorca, ib-salut, Balearic Islands, Spain.ORCID https://orcid.org/0000-0001-8728-3741
Toos van BeijsterveldtDepartment of Biological Psychology, Faculty of Behavioral and Movement Sciences, Vrije Universiteit, Amsterdam, the Netherlands.ORCID https://orcid.org/0000-0002-6617-4201
Alessia ViscontiDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.ORCID https://orcid.org/0000-0003-4144-2019
Judith M VonkDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID https://orcid.org/0000-0001-7531-4547
Carol A WangSchool of Medicine and Public Health, The University of Newcastle, Newcastle, New South Wales, Australia.ORCID https://orcid.org/0000-0002-4301-3974
Cheng-Jian XuCentre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany.ORCID https://orcid.org/0000-0003-1586-4672
Ali H ZiyabDepartment of Community Medicine and Behavioral Sciences, College of Medicine, Kuwait University, Kuwait City, Kuwait.ORCID https://orcid.org/0000-0003-3099-4424
UK Translational Research Network in Dermatology
BIOMAP Consortium
Adnan CustovicNational Heart and Lung Institute, Imperial College London, London, UK.ORCID https://orcid.org/0000-0001-5218-7071
Paola Di MeglioSt John's Institute of Dermatology and the School of Basic and Medical Sciences, King's College London, London, UK.ORCID https://orcid.org/0000-0002-2066-7780
Liesbeth DuijtsDivision of Respiratory Medicine and Allergology, and Neonatology, Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID https://orcid.org/0000-0001-6731-9452
Carsten FlohrDepartment of Paediatric Dermatology, St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK.ORCID https://orcid.org/0000-0003-4884-6286
Alan D IrvineDepartment of Clinical Medicine, Trinity College Dublin, Dublin, Ireland.ORCID https://orcid.org/0000-0002-9048-2044
Gerard H KoppelmanUniversity of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, the Netherlands.ORCID https://orcid.org/0000-0001-8567-3252
Young-Ae LeeMax-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany.
Nick J ReynoldsFaculty of Medical Sciences, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID https://orcid.org/0000-0002-6484-825X
Catherine SmithSt John's Institute of Dermatology and the School of Basic and Medical Sciences, King's College London, London, UK.ORCID https://orcid.org/0000-0001-9918-1144
Sinéad M LanganFaculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.ORCID https://orcid.org/0000-0002-7022-7441
Lavinia PaternosterMRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK.ORCID https://orcid.org/0000-0003-2514-0889
Sara J BrownCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID https://orcid.org/0000-0002-3232-5251
Funding
Asthma and Lung UKBMA James TrustEuropean Research CouncilEuropean Science FoundationGerman Federal Ministry of Education and ResearchInnovative Medicines InitiativeLung Foundation NetherlandsMedical Research CouncilMinisterio de Ciencia e InnovaciónNational Institute for Health and Care ResearchNetherlands Ministry of Health, Welfare, and SportNetherlands Ministry of Spatial Planning, Housing, and the EnvironmentNetherlands Organization for Health Research and DevelopmentNetherlands Organization for Scientific ResearchThe JP Moulton Charitable FoundationThe North West Lung Centre CharityWellcome Trust
Abstract
backgroundMultiple environmental and genetic factors play a role in the pathogenesis of atopic eczema (AE). We aimed to investigate gene-environment interactions (G × E) to improve understanding of the pathophysiology.
methodsWe analysed data from 16 European studies to test for interaction between the 24 most significant AE-associated loci identified from genome-wide association studies and 18 early-life environmental factors. We tested for replication using a further 10 studies and in vitro modeling to independently assess findings.
resultsThe discovery analysis (including 25,339 individuals) showed suggestive evidence for interaction (p < 0.05) between seven environmental factors (antibiotic use, cat ownership, dog ownership, breastfeeding, elder sibling, smoking and washing practices) and at least one established variant for AE, 14 interactions in total. In the replication analysis (254,532 individuals) dog exposure × rs10214237 (on chromosome 5p13.2 near IL7R) was nominally significant (OR
conclusionInteraction analysis and functional assessment provide preliminary evidence that early-life dog exposure may modify the genetic effect of rs10214237 on AE via IL7R, supporting observational epidemiology showing a protective effect for dog ownership. The lack of evidence for other G × E studied here implies only weak effects are likely to occur.
Indexed as
Dermatitis, AtopicGene-Environment InteractionGenetic Predisposition to DiseaseAnimalsDogsGenome-Wide Association StudyGenotypeHumansPolymorphism, Single NucleotideRisk Factorsatopic eczemadogenvironmentgeneinteraction
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