Evidence map›Paper›PMID 40462435›Full record

ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2025

[FGF19 alleviates inflammatory injury in vascular endothelial cells by activating the Nrf2/HO-1 signaling pathway].

Yan-Jun Zhang, Fei-Fei Xiao, Xiao-Hua Li, Shen-Hua Tang, Yi Sang, Chao-Yue Liu, Jian-Chang Li

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yan-Jun ZhangDepartment of Pediatrics, Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong 256603, China.
Fei-Fei XiaoDepartment of Pediatrics, Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong 256603, China.
Xiao-Hua LiDepartment of Pediatrics, Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong 256603, China.
Shen-Hua TangDepartment of Pediatrics, Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong 256603, China.
Yi SangDepartment of Pediatrics, Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong 256603, China.
Chao-Yue LiuDepartment of Pediatrics, Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong 256603, China.
Jian-Chang LiDepartment of Pediatrics, Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong 256603, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the role and mechanism of fibroblast growth factor (FGF) 19 in inflammation-induced injury of vascular endothelial cells caused by high glucose (HG).

methodsHuman umbilical vein endothelial cells (HUVECs) were randomly divided into four groups: control, HG, FGF19, and HG+FGF19 (

resultsCompared to the control group, the HG group exhibited increased apoptosis rate, increased IL-6, iNOS and MDA levels, and increased VEGF mRNA and protein expression, along with decreased T-SOD activity and decreased mRNA and protein expression of Nrf2 and HO-1 (

conclusionsFGF19 can alleviate inflammation-induced injury in vascular endothelial cells caused by HG, potentially through the Nrf2/HO-1 signaling pathway.

Indexed as

Fibroblast Growth FactorsHeme Oxygenase-1Human Umbilical Vein Endothelial CellsInflammationNF-E2-Related Factor 2Signal TransductionApoptosisCells, CulturedGlucoseHumansInterleukin-6Nitric Oxide Synthase Type IIVascular Endothelial Growth Factor AFGF19 protein, humanFibroblast Growth FactorsGlucoseHeme Oxygenase-1HMOX1 protein, humanInterleukin-6NFE2L2 protein, humanNF-E2-Related Factor 2Nitric Oxide Synthase Type IIVascular Endothelial Growth Factor AFibroblast growth factor19Human umbilical vein endothelial cellInflammationOxidative stressType 1 diabetes mellitusVascular endothelial dysfunction

Identifiers

PMID40462435
PMCPMC12169873

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.