Evidence map›Paper›PMID 40462260›Full record

ArticleACS infectious diseases2025

Chemical and Genetic Validation of an Essential Calcium Entry Channel of

Guozhong Huang, Harmanpreet Singh, Priti Singh, Rohit Kumar Varshnaya, Donald Hamelberg, Binghe Wang, Roberto Docampo

Abstract read
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Guozhong HuangCenter for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, Georgia 30602, United States.
Harmanpreet SinghDepartment of Chemistry, Georgia State University, Atlanta, Georgia 30303, United States.
Priti SinghDepartment of Chemistry, Georgia State University, Atlanta, Georgia 30303, United States.
Rohit Kumar VarshnayaDepartment of Chemistry, Georgia State University, Atlanta, Georgia 30303, United States.
Donald HamelbergDepartment of Chemistry, Georgia State University, Atlanta, Georgia 30303, United States.ORCID 0000-0002-3785-3037
Binghe WangDepartment of Chemistry, Georgia State University, Atlanta, Georgia 30303, United States.
Roberto DocampoCenter for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0003-4229-8784

Funding

Developing computational tools to complement experiments in understanding biomolecular function from conformational ensemblesR35GM153718 · NIGMS · GEORGIA STATE UNIVERSITY · PI Donald Hamelberg · 2024 to 2026
$1.2M
Piezo channels and calcium signaling in Trypanosoma cruziR21AI156096 · NIAID · UNIVERSITY OF GEORGIA · PI DOCAMPO, ROBERTO · 2021 to 2022
$415k
NIAID NIH HHS R21 AI156096NIGMS NIH HHS R35 GM153718
6 · The paper itself

Abstract

The

Indexed as

Calcium Channel BlockersCalcium ChannelsProtozoan ProteinsTrypanocidal AgentsTrypanosoma brucei bruceiAnimalsCalciumHEK293 CellsHumansMolecular Docking SimulationTrypanosomiasis, AfricanCalciumCalcium Channel BlockersCalcium ChannelsProtozoan ProteinsTrypanocidal Agentscalcium channeldocking analysistarget validationTrypanosoma bruceiyeast complementation

Identifiers

PMID40462260
PMCPMC12172032

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.