Evidence map›Paper›PMID 40462258›Full record

ArticleJournal of neuroendocrinology2025

Anorectic and anxiogenic actions of cocaine- and amphetamine-regulated transcript in the lateral septum.

Anjali Shankhatheertha, Mikayla A Payant, Jenny Phy-Lim, Melissa J Chee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroendocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Anjali ShankhatheerthaDepartment of Neuroscience, Carleton University, Ottawa, Ontario, Canada.
Mikayla A PayantDepartment of Neuroscience, Carleton University, Ottawa, Ontario, Canada.
Jenny Phy-LimDepartment of Neuroscience, Carleton University, Ottawa, Ontario, Canada.ORCID 0009-0009-1235-298X
Melissa J CheeDepartment of Neuroscience, Carleton University, Ottawa, Ontario, Canada.ORCID 0000-0003-3815-9095

Funding

Internship-Carleton University Research Experience for Undergraduate StudentsNatural Sciences and Engineering Research Council of Canada, Undergraduate Student Research Award, Postgraduate Scholarships-Doctoral, Discovery Grant RGPIN-2017-06272Natural Sciences and Engineering Research Council of Canada, Undergraduate Student Research Award, Postgraduate Scholarships-Doctoral, Discovery Grant RGPIN-2024-04133
6 · The paper itself

Abstract

Cocaine- and amphetamine-regulated transcript (CART) is produced in several brain regions including the hypothalamus where it is made in cells that also produce melanin-concentrating hormone (MCH). CART-expressing MCH cells densely innervate the lateral septum (LS), which integrates food- and mood-related behaviours. However, while MCH typically promotes feeding and anxiolysis, CART suppresses feeding and promotes anxiogenesis. The LS is a target site of orexigenic MCH actions, but it is not known if the actions of CART converge or oppose that of MCH in the LS. We implanted a bilateral cannula over the lateral or medial LS of male and female wildtype mice and infused vehicle, CART

Indexed as

AnorexiaAnxietyHypothalamic HormonesNerve Tissue ProteinsPituitary HormonesSeptal NucleiAnimalsCocaine- and Amphetamine-Regulated Transcript ProteinEatingFeeding BehaviorFemaleMaleMelaninsMiceMice, Inbred C57BLCocaine- and Amphetamine-Regulated Transcript ProteinHypothalamic Hormonesmelanin-concentrating hormoneMelaninsNerve Tissue ProteinsPituitary Hormonesanxietycocaine‐ and amphetamine‐regulated transcriptfeedinglateral septummelanin‐concentrating hormone

Identifiers

PMID40462258
PMCPMC12404906

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.