ArticleStem cell research & therapy2025
ECM remodeling by PDGFRβ+ dental pulp stem cells drives angiogenesis and pulp regeneration via integrin signaling.
Article in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Coronary Microvascular Dysfunction: Epidemiology, Pathophysiology, Diagnosis, and Treatment.MedComm · 2026Review
- Enhancing pulp regeneration through metabolic reprogramming of mature dental pulp stem cells mediated by GLUT1/HK2 mRNA delivery.International journal of oral science · 2026Article
- A histopathological case-control study of severe turner teeth and normal teeth: structural and compositional alterations in pulp and periodontal tissues.BMC oral health · 2026Article
- A microfluidic model of human dental pulp angiogenesis for preclinical drug and biomaterial testing.Materials today. Bio · 2026Article
- EXO-VNN2 derived from 3D-cultured DPSCs enhances the inflammatory response of PDLSCs and suppresses bone regeneration in periodontitis.Stem cell research & therapy · 2026Article
- Mapping the Ischemic Continuum: Dynamic Multi-Omic Biomarker and AI for Personalized Stroke Care.International journal of molecular sciences · 2026Review
- Investigations into the basal neural-like properties of dental pulp stem cells reveal they possess a functional type 2 muscarinic receptor which regulates quiescence.Stem cell research & therapy · 2025Article
- The next generation of dental treatments: Leveraging smart-responsive nanomaterials for unique oral environments.Materials today. Bio · 2025Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundThis study investigates the role of PDGFRβ+ dental pulp stem cells (DPSCs) in dental pulp vascular development by remodeling the extracellular matrix (ECM), with implications for angiogenesis and pulp regeneration using GelMA hydrogels.
methodsPDGFRβ+ DPSCs were assessed for ECM remodeling and angiogenesis via secretion of ECM proteins (FN, LAMA4, COL1A2). Immunofluorescence and gene expression analyses were performed to evaluate ECM composition and related signaling pathways. GelMA hydrogels loaded with PDGFRβ+ DPSCs were tested for angiogenic support in vitro (HUVEC tube formation) and in vivo (subcutaneous implantation in mice for 6 weeks).
resultsPDGFRβ+ DPSCs enhanced ECM deposition and modulated angiogenic signaling, promoting vascular development. Encapsulation in GelMA hydrogels supported HUVEC tube formation and facilitated organized pulp-like tissue with increased ECM and angiogenesis in vivo. Integrin pathway inhibition diminished these effects, highlighting the importance of ECM-integrin signaling in angiogenesis.
conclusionPDGFRβ+ DPSCs regulate dental pulp vascular development through ECM remodeling. Their encapsulation in GelMA hydrogels provides a promising strategy for pulp regeneration by establishing an ECM-mediated angiogenic environment, offering potential for clinical pulp-dentin complex repair.
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Registered trials
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