Evidence map›Paper›PMID 40462232›Full record

ArticleCell & bioscience2025

Linear ubiquitination of p31

Yifeng Gao, Qing Yin, Yaser Gamallat, Michael G Grant, Aidan H Snell, Xingxing Shi, Lara N Ulstad, Arshita Singh, Tingan Chen, Joseph O Johnson and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell & bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yifeng Gao *Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Qing Yin *Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Yaser GamallatDepartment of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Michael G GrantDepartment of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Aidan H SnellDepartment of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Xingxing ShiDepartment of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Lara N UlstadDepartment of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Arshita SinghDepartment of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Tingan ChenAnalytic Microscopy Core Facility, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Joseph O JohnsonAnalytic Microscopy Core Facility, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Dorina AvramDepartment of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Lixin WanDepartment of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA. lixin.wan@moffitt.org.ORCID http://orcid.org/0000-0002-9759-5113

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5M
Characterizing oncogenic function of ITCH in melanomaR01CA255398 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI Lixin Wan · 2021 to 2026
$1.8M
A Novel Oncogenic Role for Cdc20 Implications in Adult T Cell Leukemia TreatmentR00CA183914 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI WAN, LIXIN · 2016 to 2018
$652k
A Novel Oncogenic Role for Cdc20 Implications in Adult T Cell Leukemia TreatmentK99CA183914 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WAN, LIXIN · 2014 to 2015
$339k
American Cancer Society RSG-19-226-01-TBEFlorida Department of State 23B10NCI NIH HHS CA183914NCI NIH HHS CA255398NCI NIH HHS K99 CA183914NCI NIH HHS P30 CA076292NCI NIH HHS R00 CA183914NCI NIH HHS R01 CA255398
6 · The paper itself

Abstract

backgroundInflammation and genomic instability are among the hallmarks of human cancer. Proinflammatory cytokines induce DNA damage through the accumulation of reactive oxygen and nitrogen species (RONS), which often leads to base alternations. The link between proinflammatory cytokines and chromosomal instability remains largely elusive.

resultsHere, we report that the mitotic checkpoint protein p31

conclusionsOur results together uncover a mechanistic link between the proinflammatory cytokines and the mitotic checkpoint pathways. This molecular switch could be explored as a potential therapeutic target in inflammation-driving or p31

Indexed as

Anaphase-promoting complexCDC20HOIPLUBACMitotic checkpoint complexP31cometProinflammatory cytokineSpindle assembly checkpoint

Identifiers

PMID40462232
PMCPMC12135451

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.