ArticleInfectious diseases of poverty2025
One Health integrated strategies for sustainable control of Opisthorchis viverrini infections in rural endemic areas of Thailand.
Article in Infectious diseases of poverty, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- From infection to cholangiocarcinoma: Why opisthorchiids break these rules.One health (Amsterdam, Netherlands) · 2026Review
- A systematic review of selected food-borne helminthiases in Southeast Asia with emphasis on anthelminthic treatment regimens.Food and waterborne parasitology · 2026Article
- A data-driven approach for mitigation of fecal pathogen infections from unsafe WASH practices.One health (Amsterdam, Netherlands) · 2026Article
- Evaluating the impact of the 'Four Pest-Free Villages' program on mosquito-borne disease control in Zhejiang Province, China: a cross-sectional study on knowledge, attitudes, and practices.Infectious diseases of poverty · 2026Article
- Fish-borne trematode metacercarial infections as bioindicators for heavy-metal contamination in cyprinoid fish from Northeastern Thailand.Food and waterborne parasitology · 2026Article
- Prevalence and risk factors of human trichostrongylosis in Satun, southern Thailand.Parasite (Paris, France) · 2026Article
- Behavioral Medicine in Cholangiocarcinoma: Bridging the Gap Between Biology and Behavior.Cancer control : journal of the Moffitt Cancer CenterReview
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8 authors.
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Abstract
backgroundOpisthorchiasis, caused by Opisthorchis viverrini, poses a significant health risk in northeastern Thailand, increasing the prevalence of cholangiocarcinoma. This study implemented a One Health integrated strategy, targeting human, animal, and environmental factors to reduce O. viverrini prevalence and transmission in an endemic region.
methodsThe study was conducted from 2016 to 2022 in the Huay Luang Reservoir area, Udon Thani Province, Thailand and enrolled 5412 participants. Annual stool examinations were conducted and participants found to be infected with O. viverrini received anthelmintic treatments. Other intervention methods included health education, snail control, veterinary care, sanitation improvements, training of health volunteers, creating a learning center and liver fluke-free fish production. Annual data on prevalence, infection intensity, and reinfection rates were collected. Student's t-test, one-way ANOVA, Chi-square test, or Fisher's exact test were used to compare data across the study years, with statistical significance set at P < 0.05.
resultsThe One Health strategy significantly reduced O. viverrini prevalence in humans from 14.1% in 2016 to 0.9% in 2022, with O. viverrini-egg intensity decreasing from 76.9 to 25.5 eggs per gram (EPG) (P < 0.001). Reinfection rates decreased significantly from 17.4% in 2016 to 9.7% in 2022 following the implementation of the program (P = 0.003). Among reservoir hosts, infections in dogs and cats significantly decreased from 21.3% to 3.8% (P < 0.001). In cyprinoid fish, metacercarial prevalence significantly decreased from 21.9% to 2.2% (P < 0.001). Awareness of transmission routes rose from 45.1% to 82.6%, and raw fish consumption decreased from 52.4% to 12.3%. Biological control reduced Bithynia snail densities from 30 to under 5 snails/m
conclusionsThe One Health strategy effectively and sustainably limited O. viverrini infections and reinfections, demonstrating the potential of One Health as a model for zoonotic parasite control in other endemic areas.
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