Evidence map›Paper›PMID 40462166›Full record

Observational studyCritical care (London, England)2025

Diagnostic performance of the recruitment-to-inflation ratio to assess lung recruitability by PEEP in ARDS. a computed tomography study.

Jean-Christophe Richard, Francois Dhelft, Guillaume Deniel, Emmanuel Roux, Hodane Yonis, Mehdi Mezidi, Louis Chauvelot, Maxime Gaillet, Ines Noirot, Eduardo Davila and 7 more

Abstract readObservational Study
In one paragraph

Observational study in Critical care (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jean-Christophe RichardService de Médecine Intensive Réanimation, Hôpital de La Croix Rousse, Hospices Civils de Lyon, 103 Grande Rue de La Croix Rousse, 69004, Lyon, France. j-christophe.richard@chu-lyon.fr.
Francois DhelftService de Médecine Intensive Réanimation, Hôpital de La Croix Rousse, Hospices Civils de Lyon, 103 Grande Rue de La Croix Rousse, 69004, Lyon, France.
Guillaume DenielService de Médecine Intensive Réanimation, Hôpital de La Croix Rousse, Hospices Civils de Lyon, 103 Grande Rue de La Croix Rousse, 69004, Lyon, France.
Emmanuel RouxINSA-Lyon, CNRS, INSERM, CREATIS UMR 5220, Univ Lyon, Université Claude Bernard Lyon 1, U1294, Villeurbanne, France.
Hodane YonisService de Médecine Intensive Réanimation, Hôpital de La Croix Rousse, Hospices Civils de Lyon, 103 Grande Rue de La Croix Rousse, 69004, Lyon, France.
Mehdi MezidiService de Médecine Intensive Réanimation, Hôpital de La Croix Rousse, Hospices Civils de Lyon, 103 Grande Rue de La Croix Rousse, 69004, Lyon, France.
Louis ChauvelotService de Médecine Intensive Réanimation, Hôpital de La Croix Rousse, Hospices Civils de Lyon, 103 Grande Rue de La Croix Rousse, 69004, Lyon, France.
Maxime GailletService de Médecine Intensive Réanimation, Hôpital de La Croix Rousse, Hospices Civils de Lyon, 103 Grande Rue de La Croix Rousse, 69004, Lyon, France.
Ines NoirotService de Médecine Intensive Réanimation, Hôpital de La Croix Rousse, Hospices Civils de Lyon, 103 Grande Rue de La Croix Rousse, 69004, Lyon, France.
Eduardo DavilaINSA-Lyon, CNRS, INSERM, CREATIS UMR 5220, Univ Lyon, Université Claude Bernard Lyon 1, U1294, Villeurbanne, France.
Rosalie SchouxService de Médecine Intensive Réanimation, Hôpital de La Croix Rousse, Hospices Civils de Lyon, 103 Grande Rue de La Croix Rousse, 69004, Lyon, France.
Yorick RodriguezService de Médecine Intensive Réanimation, Hôpital de La Croix Rousse, Hospices Civils de Lyon, 103 Grande Rue de La Croix Rousse, 69004, Lyon, France.
Florent BaudinService de Réanimation Pédiatrique, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Bron, France.
Ludmilla PenarrubiaINSA-Lyon, CNRS, INSERM, CREATIS UMR 5220, Univ Lyon, Université Claude Bernard Lyon 1, U1294, Villeurbanne, France.
Loic BousselUniversité de Lyon, Université Claude Bernard Lyon 1, Villeurbanne, France.
Maciej OrkiszINSA-Lyon, CNRS, INSERM, CREATIS UMR 5220, Univ Lyon, Université Claude Bernard Lyon 1, U1294, Villeurbanne, France.
Laurent BitkerService de Médecine Intensive Réanimation, Hôpital de La Croix Rousse, Hospices Civils de Lyon, 103 Grande Rue de La Croix Rousse, 69004, Lyon, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe recruitment-to-inflation (R/I) ratio is a new bedside tool with potential to evaluate lung recruitability by positive end-expiratory pressure (PEEP) but was only validated using pressure-volume curves and the optimal threshold separating low and high recruiters by PEEP is not precisely known. The aim of the study is to evaluate the diagnostic performance of the R/I ratio using computed tomography (CT) as a gold standard in patients with acute respiratory distress syndrome (ARDS).

methodsThis study is a single-center prospective observational study performed on adults ARDS patients under invasive mechanical ventilation. The R/I ratio was measured with the ventilator, and low-dose CT scans were acquired at PEEP 15 and 5 cmH

resultsFifty patients were included, and eight patients were secondarily excluded (7/50 [14%] for suspected air leaks, and 1/50 [2%] for airway opening pressure > 15 cmH

conclusionsIn a population of ARDS patients with low recruitment potential, the R/I ratio had a poor diagnostic performance to predict lung recruitability, but R/I ratio values below 0.57 reliably identified ARDS patients with low recruitability, provided they did not present focal ARDS.

Indexed as

LungPositive-Pressure RespirationRespiratory Distress SyndromeTomography, X-Ray ComputedAdultAgedFemaleHumansMaleMiddle AgedProspective StudiesAcute respiratory distress syndromeAlveolar recruitmentComputed tomographyPositive end expiratory pressureRecruitment-to-inflation ratio

Identifiers

PMID40462166
PMCPMC12131414

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.