Evidence map›Paper›PMID 40462163›Full record

Trial reportBMC research notes2025

A single presumptive deworming may not suffice to reduce the burden of intestinal parasitic infections during pregnancy in rural Amhara, Ethiopia.

Kalkidan Yibeltal, Firehiwot Workneh, Nebiyou Fasil, Estifanos Baye, Yunhee Kang, Workagegnhu Tarekegn Kidane, Sitota Tsegaye, Yoseph Yemane Berhane, Bethlehem Haymanot, Ingrid E Olson and 8 more

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC research notes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Kalkidan YibeltalDepartment of Reproductive Health and Population, Addis Continental Institute of Public Health, Addis Ababa, Ethiopia. kalkidanyibeltal@addiscontinental.edu.et.
Firehiwot WorknehDepartment of Epidemiology and Biostatistics, Addis Continental Institute of Public Health, Addis Ababa, Ethiopia.
Nebiyou FasilDepartment of Global Health and Health Policy, Addis Continental Institute of Public Health, Addis Ababa, Ethiopia.
Estifanos BayeDepartment of Pediatrics, Brigham and Women's Hospital, Boston, MA, USA.
Yunhee KangCenter for Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Workagegnhu Tarekegn KidaneDepartment of Nutrition and Behavioral Science, Addis Continental Institute of Public Health, Addis Ababa, Ethiopia.
Sitota TsegayeDepartment of Nutrition and Behavioral Science, Addis Continental Institute of Public Health, Addis Ababa, Ethiopia.
Yoseph Yemane BerhaneDepartment of Epidemiology and Biostatistics, Addis Continental Institute of Public Health, Addis Ababa, Ethiopia.
Bethlehem HaymanotAddis Continental Institute of Public Health, Bahir Dar, Ethiopia.
Ingrid E OlsonDepartment of Pediatrics, Brigham and Women's Hospital, Boston, MA, USA.
Mulatu Melese DerebeAmhara Public Health Institute, Bahir Dar, Ethiopia.
Rose L MolinaHarvard Medical School, Boston, MA, USA.
Blair J WylieDepartment of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, USA.
Grace J ChanHarvard Medical School, Boston, MA, USA.
Parul ChristianCenter for Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Alemayehu WorkuDepartment of Epidemiology and Biostatistics, Addis Continental Institute of Public Health, Addis Ababa, Ethiopia.
Anne Cc LeeDepartment of Pediatrics, Brigham and Women's Hospital, Boston, MA, USA. anne_cc_lee@brown.edu.
Yemane BerhaneDepartment of Epidemiology and Biostatistics, Addis Continental Institute of Public Health, Addis Ababa, Ethiopia. Yemaneberhane@addiscontinental.edu.et.

Funding

Nutrition and Inflammation in Pregnancy: Impacts on Early Human Brain DevelopmentR01HD106106 · NICHD · BROWN UNIVERSITY · PI Anne Shee CC Lee · 2022 to 2026
$3.5M
Bill and Melinda Gates Foundation OPP1184363, INV-045894NICHD NIH HHS R01 HD106106
6 · The paper itself

Abstract

objectiveThis study aimed to assess the prevalence of intestinal parasitic infections among pregnant women in the third trimester who received prior presumptive deworming in 12 health centers in the Amhara region, Ethiopia. This sub-study was part of the parent Enhancing Nutrition and Antenatal Infection Treatment (ENAT) study; a randomized clinical effectiveness study conducted to determine the effectiveness of packages of antenatal interventions to enhance maternal nutrition and infection management on birth outcomes.

resultsThree hundred fifty women provided a stool sample in their 3rd trimester for screening using wet mount microscopy. All women had previously received 500 mg of presumptive mebendazole in the 2nd trimester. One in three women (109/350, 31.0%) were found to have a parasitic stool infection after prior deworming and 15% of women reported gastrointestinal symptoms. The most common infections were Giardia lamblia (n = 43, 37.4%), Entamoeba histolytica (n = 40, 34.8%), and Hookworm (n = 25, 21.7%). Six mothers had co-infections with at least two parasites with trophozoites of Giardia lamblia and Entamoeba histolytica co-infection being dominant.

Indexed as

AnthelminticsIntestinal Diseases, ParasiticMebendazolePregnancy Complications, ParasiticAdolescentAdultEthiopiaFecesFemaleGiardia lambliaGiardiasisHumansPregnancyPrevalenceRural PopulationYoung AdultAnthelminticsMebendazoleDewormingEthiopiaInfectionIntestinal parasitePregnancy

Identifiers

PMID40462163
PMCPMC12135545

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.