ArticleMilitary Medical Research2025
Social jetlag elicits fatty liver via perturbed circulating prolactin rhythm-mediated circadian remodeling of hepatic lipid metabolism.
Article in Military Medical Research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Targeting the NR1D1-IGF2BP2-V-ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis-Induced Immunosuppression.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- ZDHHC5: a pivotal palmitoyltransferase orchestrating signaling networks - unraveling mechanisms and therapeutic horizons.Biomarker research · 2026Review
- Review
- From the perspective of prolactin: a view on obesity.Frontiers in endocrinology · 2026Review
- Interplay between circadian rhythms, gut microbiota, and MASLD: from mechanistic foundations to therapeutic opportunities.Frontiers in medicine · 2026Review
- The association between sleep duration, insomnia and sleep patterns with metabolic syndrome: an integrative review.Frontiers in clinical diabetes and healthcare · 2026Review
- Review
- Involvement of ferroptosis in metabolic dysfunction-associated steatohepatitis-related liver diseases.Journal of molecular medicine (Berlin, Germany) · 2025Review
- Diet and Lifestyle Interventions in Metabolic Dysfunction-Associated Fatty Liver Disease: A Comprehensive Review.International journal of molecular sciences · 2025Review
- Bioinspired Prolactin Pulse Release from Responsive Microneedles for Inhibiting Fatty Liver Formation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
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9 authors.
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Abstract
backgroundThe prevalence of circadian misalignment, particularly social jetlag (SJL), contributes significantly to the epidemic of metabolic disorders. However, the precise impact of SJL on the liver has remained poorly elucidated.
methodsThe rhythmicity of circulating prolactin (PRL) was evaluated in subjects with SJL and mice under SJL. The causative mechanism of SJL on fatty liver was explored using jetlag model in wild-type and Prl
resultsSJL increases the risk of metabolic dysfunction-associated steatotic liver disease (MASLD), mediated by the disruption of the rhythmicity of serum PRL. In particular, SJL inhibits the rhythmic transcription of PRL in the pituitary, leading to desynchronized PRL levels in circulation. Under jetlag conditions, the rhythmicity of the hepatic PRL signaling pathway was significantly dampened, which resulted in increased lipogenesis via inhibited hepatic mitogen-activated protein kinase/cyclin D1 expressions. Notably, PRL treatment at PRL nadir in jetlagged mice decreased hepatic lipid content and liver injury markers to a greater extent compared with conventional PRL administration.
conclusionsReprogrammed hepatic PRL signaling pathway with concomitant dysregulated lipid metabolism homeostasis was the causative mechanism of fatty liver under SJL, which was mediated through derailed serum PRL rhythm. Restoration of PRL rhythm could effectively alleviate SJL-induced fatty liver, providing new insight into treating MASLD.
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