Trial reportBMC oral health2025
Comparative evaluation of BRIX3000 and Carisolv in chemomechanical caries removal in immature permanent first molars: a randomized controlled trial.
Trial report in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparative efficacy of chemomechanical caries removal and conventional mechanical caries removal for the treatment of primary molar caries in children: a meta-analysis.BMC oral health · 2026Pooled it
- Caries removal efficiency and minimally invasive potential of SmartPrep burs, Brix 3000, and excavus: A micro-computed tomography comparative study.Journal of conservative dentistry and endodontics · 2026Article
- Clinical and Biological Evaluation of Chemo-Mechanical Caries Excavation with Brix 3000 in Primary Molars: An 18-Month Prospective Study.Medicina (Kaunas, Lithuania) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to compare the efficacy of BRIX3000, Carisolv, and the conventional rotary-mechanical method for caries removal and to evaluate the intraoperative pain level and the requirement for local anesthesia during caries excavation in immature mandibular permanent first molars (PFMs) of pediatric patients aged 7 to 9. MATERIALS AND
methodsIt was a single-blinded, randomized, parallel-group, active-controlled trial with three arms. Forty-five specimens were assigned randomly to three groups: Group 1: Chemomechanical caries removal (CMCR) utilizing Carisolv. Group 2: CMCR utilizing BRIX3000. Group 3: Control group, caries excavation utilizing conventional rotary-mechanical method. Lesions reaching the middle or inner third of the dentine (D2/3) were observed in immature mandibular PFMs with no pulpal and/or periodontal issues included. The efficacy of caries removal was considered the primary outcome measure. It was recorded using the Ericson et al. scale by visual-tactile examination and the caries detector, which includes five levels to rate the amount of carious dentin remaining. The secondary outcome measures were subjective and objective pain assessment and the requirement of local anesthesia. Continuous and categorical data were compared using the Kruskal-Wallis and chi-square tests, respectively. A significance level of p < 0.05 was adjusted.
resultsAll conventional-method cases (100%) and the majority of Carisolv and BRIX3000 cases (80%) showed complete caries removal and a mean score of (0.27 ± 0.59) and (0.20 ± 0.41) (p = 0.185), respectively. The conventional method group showed the highest mean score (2.07 ± 0.88) of the sound, eye, motor (SEM) scale compared with the Carisolv and BRIX3000 (p < 0.05) groups, which exhibit lower mean scores (0.80 ± 0.77), (0.67 ± 0.72), respectively. For the Wong-Baker FACES scale, the conventional method group recorded the highest mean (7.07 ± 3.01) compared to the Carisolv and BRIX3000 (p < 0.05) groups, which had considerably lower mean scores of (2.53 ± 2.77) and (2.00 ± 2.39), respectively. Consequently, the majority (80.00%) of conventional-method cases asked for local anesthesia (p < 0.05).
conclusionsAll methods were equally effective in removing caries. BRIX 3000 and Carisolv agents notably reduced pain in children.
trial registrationISRCTN registry, ISRCTN12761284, registered 6 November 2024, retrospectively.
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