SynthesisBMC oral health2025
Efficacy of bioactive glass-based desensitizer compared to other desensitizing agents or techniques in dentin hypersensitivity: a systematic review.
Synthesis in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Effectiveness of S-PRG-based varnish and bioactive glass-based air polishing in the management of dentin hypersensitivity and their effects on tooth color: a 12-month randomized clinical trial.BMC oral health · 2026Trial
- Longevity of different in-office treatments for dentin hypersensitivity: A 6-month randomized and parallel clinical trial.PloS one · 2026Trial
- Comparative Effects of Experimental Bioactive Glasses on Dentin Permeability and Tubule Occlusion In Vitro.Journal of functional biomaterials · 2026Article
- Effect of eggshell nanoparticles and fluoride varnish, with and without diode laser, on dentinal tubule occlusion (An in vitro study).BMC oral health · 2026Article
- From Industry to Dentistry: A Comprehensive Review of Zeolite as a Next-Generation Multifunctional Filler for Enhanced Mechanical Reinforcement and Antimicrobial Efficacy.Dentistry journal · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe objective of this systematic review was to evaluate the effectiveness of home and professional single-application desensitizers that contain bioactive glass in comparison to other desensitizing methods and agents or negative controls in randomized controlled trials.
methodsTwo reviewers searched the electronic databases Cochrane Central Library, PubMed, Scopus, and Web of Science using specific keywords. The randomized controlled clinical trials (RCTs) that focused on the use of bioactive glass-based desensitizers to treat dentin hypersensitivity (DH) through December 2024 were included. Data extraction, selection, and screening were completed. Descriptive analyses were conducted, and the Critical Appraisal Skills Programme (CASP) and updated Cochrane tools were used to evaluate the quality assessment and risk of bias, respectively.
resultsA total of 30 studies were involved in this evaluation, and all of them were assessed as low risk of bias except one that had some concerns. Pain responses of 2845 patients with an age range of 17-75 years were assessed in this review. The efficacy of bioactive glass-based desensitizers in reducing sensitivity pain was superior compared to baseline and to various desensitizing agents and placebo. The follow-up assessment time was varied, and accordingly, the long-term efficacy of bioactive glass was similar to other agents.
conclusionsWith the limitation of this review, the bioactive-glass-based desensitizing agent used in-office or at home is effective to reduce DH response in the immediate, medium, or long term up to 12 weeks. The efficacy of this agent is comparable to most of the available desensitizers in the long term; however, it is more effective in the immediate to medium term, up to 4 weeks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.