ReviewBMC nephrology2025
Dental amalgam associated with SAPHO syndrome and IgA nephropathy: a case report and literature review.
Review in BMC nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Response to "Conclusions about a link between SAPHO syndrome, IgA nephropathy and dental amalgams can only be drawn after extensive analysis" by Delrieu et al.BMC nephrology · 2026Article
- Conclusions about a link between SAPHO syndrome, IgA nephropathy and dental amalgams can only be drawn after extensive analysis.BMC nephrology · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
Abstract
backgroundExposure to metals is associated with adverse health effects, including multiorgan damage and dysregulation of systemic immune responses. The increasing use of metallic implants in humans, such as dental materials and orthopedic devices, has resulted in chronic endogenous exposure to metal ions. The pathophysiological mechanisms underlying implant-related complications and their clinical implications have not been fully elucidated. CASE PRESENTATION: We present a case of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome coexisting with IgA nephropathy (IgAN) in the context of dental amalgam exposure. Following amalgam placement, the patient developed palmoplantar pustulosis (PPP) and sternoclavicular arthritis, with a subsequent diagnosis of IgAN. Notably, all the clinical manifestations were markedly resolved after amalgam removal.
conclusionThis case suggests a potential link between SAPHO syndrome, IgAN, and dental amalgam exposure. To our knowledge, this is the first reported case linking these conditions. Further studies are needed to elucidate the mechanisms and clinical implications of metal-induced autoimmune or inflammatory responses. CLINICAL TRIAL NUMBER: Not applicable.
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