Evidence map›Paper›PMID 40461899›Full record

ArticleAnalytical and bioanalytical chemistry2025

Hydrophilic deep eutectic solvents for bioactive compound extraction from Rubia tinctorum L.

Tatiana Bochko, Elena Andrusenko, Ruslan Glushakov, Galina Melnikova, Andrey Shishov

Abstract read
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Article in Analytical and bioanalytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tatiana BochkoDepartment of Analytical Chemistry, Institute of Chemistry, Saint-Petersburg University, Saint Petersburg State University, SPbSU, SPbU, 7/9 Universitetskaya nab., St. Petersburg, 199034, Russia.
Elena AndrusenkoMilitary Medical Academy n.a. S.M. Kirov of Ministry of defense of the Russian Federation, Akademika Lebedeva st., 6, St. Petersburg, 194044, Russia.
Ruslan GlushakovMilitary Medical Academy n.a. S.M. Kirov of Ministry of defense of the Russian Federation, Akademika Lebedeva st., 6, St. Petersburg, 194044, Russia.
Galina MelnikovaA.V. Luikov Heat and Mass Transfer Institute of NAS of Belarus, Brovki, 15, 220072, Minsk, Belarus.
Andrey ShishovDepartment of Analytical Chemistry, Institute of Chemistry, Saint-Petersburg University, Saint Petersburg State University, SPbSU, SPbU, 7/9 Universitetskaya nab., St. Petersburg, 199034, Russia. a.y.shishov@spbu.ru.

Funding

Saint Petersburg State University 103753335
6 · The paper itself

Abstract

Rubia tinctorum L. roots are a valuable source of anthraquinones and other bioactive phytochemicals. In this study, nine hydrophilic deep eutectic solvents (DESs), based on choline chloride or tetrabutylammonium bromide, were evaluated as green extractants for the selective recovery of bioactive compounds. Their performance was compared with four conventional solvents (acetonitrile, methanol, ethanol-water, and water). Among DESs, choline chloride-lactic acid and choline chloride-malonic acid showed the highest extraction efficiency for gallic acid, caffeine, quercetin, alizarin, and purpurin. Extraction conditions were optimized using response surface methodology. The antioxidant, antimicrobial, and phytochemical profiles of the resulting extracts were comprehensively evaluated. GC-MS analysis revealed the presence of key metabolites including alizarin, rubiadin, purpurin, scillarenin, and fucosterol. The results demonstrate the potential of hydrophilic DESs as sustainable, efficient, and selective media for the extraction of biologically active compounds from plant materials.

Indexed as

Deep Eutectic SolventsPhytochemicalsPlant ExtractsRubiaAnti-Infective AgentsAntioxidantsGas Chromatography-Mass SpectrometryHydrophobic and Hydrophilic InteractionsPlant RootsAnti-Infective AgentsAntioxidantsDeep Eutectic SolventsPhytochemicalsPlant ExtractsAnthraquinonesAntimicrobial activityDeep eutectic solventsPhenolic compoundsRubia tinctorum L.Ultrasound-assisted extraction

Identifiers

PMID40461899

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.