ReviewInternational ophthalmology2025
Biomechanical properties of the trabecular meshwork in intraocular pressure regulation: a review.
Review in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Composition Matters: Collagen vs Polyacrylamide Modulates Distinct Trabecular Meshwork Cell Traction.ACS biomaterials science & engineering · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundGlaucoma is an irreversible blinding eye disease caused by elevated intraocular pressure. The trabecular meshwork plays a major role in maintaining intraocular pressure homeostasis and regulating aqueous humor outflow, with its drainage function responding to different mechanical stimuli.
findingsStudies in glaucoma patients and high intraocular pressure animal models reveal that abnormal elevation of intraocular pressure is frequently accompanied by changes in the biomechanical parameters of the trabecular meshwork (at the tissue, cellular, and extracellular matrix levels). Abnormalities in these biomechanical parameters affect aqueous humor outflow through the trabecular meshwork. Consequently, abnormal trabecular meshwork biomechanics may be a key factor contributing to the inadequate efficacy of intraocular pressure-lowering drugs in glaucoma patients.
conclusionAbnormal biomechanical properties of the trabecular meshwork play a critical role in aqueous humor outflow disorders. SIGNIFICANCE: This understanding enhances insight into the importance of abnormal trabecular meshwork biomechanics and provides a reference for exploring novel targeted drugs aimed at improving trabecular meshwork aqueous humor drainage function.
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Registered trials
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