Evidence map›Paper›PMID 40461864›Full record

ArticleInternal and emergency medicine2025

Prognostic impact of right ventricular dysfunction in patients with severe aortic stenosis treated with trans-catheter aortic valve implantation.

Valentina Scheggi, Yohann Bohbot, Jasim Hasan, Pierre Vanhaecke, Carlo Fumagalli, Francesco Meucci, Manuel Garofalo, Ruggero Mazzotta, Samuele Salvi, Giorgia Panichella and 12 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Internal and emergency medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Valentina ScheggiDivision of Internal Medicine, Cardiothoracovascular Department, Azienda Ospedaliero-Universitaria Careggi and University of Florence, Florence, Italy.
Yohann BohbotDepartment of Cardiology, Amiens University Hospital, Amiens, France.
Jasim HasanDepartment of Cardiology, Amiens University Hospital, Amiens, France.
Pierre VanhaeckeDepartment of Cardiology, Amiens University Hospital, Amiens, France.
Carlo FumagalliDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Francesco MeucciDivision of Internal Medicine, Cardiothoracovascular Department, Azienda Ospedaliero-Universitaria Careggi and University of Florence, Florence, Italy.
Manuel GarofaloDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy. manuel.garofalo@unifi.it.ORCID 0009-0007-6011-0710
Ruggero MazzottaDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Samuele SalviDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Giorgia PanichellaDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Lucrezia BiagiottiDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Matteo OrlandiDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Angela Ilaria FanizziDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Nicola ZoppettiInstitute of Applied Physics "Nello Carrara" (IFAC), National Research Council, Sesto Fiorentino, Italy.
Renato ValentiDivision of Internal Medicine, Cardiothoracovascular Department, Azienda Ospedaliero-Universitaria Careggi and University of Florence, Florence, Italy.
Alfredo CerilloDivision of Internal Medicine, Cardiothoracovascular Department, Azienda Ospedaliero-Universitaria Careggi and University of Florence, Florence, Italy.
Pier Luigi StefànoDivision of Internal Medicine, Cardiothoracovascular Department, Azienda Ospedaliero-Universitaria Careggi and University of Florence, Florence, Italy.
Carlo Di MarioDivision of Internal Medicine, Cardiothoracovascular Department, Azienda Ospedaliero-Universitaria Careggi and University of Florence, Florence, Italy.
Dan RusinaruDepartment of Cardiology, Amiens University Hospital, Amiens, France.
Anfani MirodeDepartment of Cardiology, Amiens University Hospital, Amiens, France.
Christophe TribouilloyDepartment of Cardiology, Amiens University Hospital, Amiens, France.
Niccolò MarchionniDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcatheter aortic valve implantation (TAVI) is a standard treatment for severe aortic stenosis (AS), especially in high-risk surgical patients. However, the impact of right ventricular (RV) dysfunction on TAVI outcomes remains unclear. This study aimed to evaluate RV function, measured by tricuspid annular plane systolic excursion (TAPSE), as a predictor of mortality post-TAVI. In a multicenter retrospective cohort study, 637 patients with severe AS who underwent TAVI were assessed for RV function using TAPSE measurements. Data were analyzed to explore the relationship between TAPSE and mortality at 30 days and 1 year, adjusting for demographic factors, comorbidities, and echocardiographic parameters. The prognostic value of the RV-pulmonary artery coupling parameter (TAPSE/PASP) was also investigated. A reduced TAPSE was identified as an independent predictor of 30-day mortality, with each 1-mm increase in TAPSE linked to a 14% reduction in mortality risk (HR 0.86 [95% CI 0.76-0.99]; p = 0.033). The association between TAPSE and 1-year mortality was weaker, with long-term outcomes more strongly influenced by the Charlson Comorbidity Index (CCI) (HR 1.2 [95% CI 1.0-1.3]; p = 0.007). In addition, TAPSE/PASP showed no significant correlation with mortality outcomes. Reduced TAPSE is a valuable predictor of early mortality following TAVI, suggesting that preoperative TAPSE assessments may enhance risk stratification and early post-procedural management. In contrast, long-term mortality in TAVI patients appears to depend more on overall comorbidity burden. Future research should consider integrating TAPSE into risk models to improve individualized TAVI patient care.

Indexed as

Aortic Valve StenosisTranscatheter Aortic Valve ReplacementVentricular Dysfunction, RightAgedAged, 80 and overCohort StudiesEchocardiographyFemaleHumansMalePrognosisRetrospective StudiesSeverity of Illness IndexAortic stenosisMortalityOutcomesRight ventricular dysfunctionSurvivalTranscatheter aortic valve implantationTricuspid annulus plane systolic excursion

Identifiers

PMID40461864

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.