Evidence map›Paper›PMID 40461770›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2025

Factorial vignettes describe suspected early onset sepsis practice variation in a multicenter NICU antibiotic stewardship collaborative.

Neha S Joshi, Kenneth M Zangwill, Henry C Lee, Peter Mendel, Chau Pham, Megan Schuler, Nabeel Qureshi, Natalie Chapkis, Allison Henry, Kurlen S E Payton

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Neha S JoshiStanford University, Stanford, CA, USA. nsjoshi@stanford.edu.ORCID http://orcid.org/0000-0003-2397-1662
Kenneth M ZangwillDivision of Pediatric Infectious Disease, The Lundquist Institute at Harbor-UCLA Medical Center, Carson, CA, USA.
Henry C LeeUniversity of California San Diego, San Diego, CA, USA.ORCID http://orcid.org/0000-0001-8383-1720
Peter MendelRAND Corporation, Santa Monica, CA, USA.
Chau PhamRAND Corporation, Santa Monica, CA, USA.
Megan SchulerRAND Corporation, Santa Monica, CA, USA.
Nabeel QureshiRAND Corporation, Santa Monica, CA, USA.
Natalie ChapkisUniversity of Washington, Seattle, WA, USA.
Allison HenryCedars-Sinai Medical Center, Los Angeles, CA, USA.
Kurlen S E PaytonCedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-2790-5849

Funding

U.S. Department of Health & Human Services | Agency for Healthcare Research and Quality (AHRQ) R18HS026168
6 · The paper itself

Abstract

objectiveTo describe provider practice preferences for term infants with suspected early-onset sepsis and preference change over time during a multicenter antibiotic stewardship collaborative. STUDY

designFactorial case vignette surveys conducted at baseline of a quality improvement collaborative, and follow up after the 12 month collaborative intervention.

resultsBaseline and follow up surveys were completed by 252 (72%) and 195 (55%) respondents, respectively. The results describe both areas of compliance and non-compliance with national guidelines. There was a reduction in likelihood of ordering laboratory testing between surveys (p values ranging <0.001-0.033). A stewardship score was calculated and the mean score moved towards more stewardship friendly practices (0.39 vs 0.30).

conclusionWe identified specific antibiotic use practice variations as potential targets for improving clinician prescribing practice in the NICU setting. Respondents moved towards more antibiotic stewardship friendly practices from baseline to the follow up survey. Vignettes methods may help optimize quality improvement.

Indexed as

Anti-Bacterial AgentsAntimicrobial StewardshipGuideline AdherenceIntensive Care Units, NeonatalNeonatal SepsisPractice Patterns, Physicians'SepsisFemaleHumansInfant, NewbornMaleQuality ImprovementSurveys and QuestionnairesAnti-Bacterial Agents

Identifiers

PMID40461770

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.