ArticleScientific reports2025
RNase 7 and Th cytokines synergistically increase the secretion of interleukin-6 from keratinocytes.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Role of human RNase 7 in neuronal and glial cell models: moving towards an unexpected new functional link.The FEBS journal · 2026Article
- mRNA and microRNA Expression Profile of Corneal and Conjunctival Impression Cytology Samples.Biology · 2026Article
- Peptide-enriched hydrogel formulation for sensitive and damaged skin: from design to application testing.Scientific reports · 2026Article
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Authors and funding
10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Epidermal keratinocytes are a major source of antimicrobial peptides and proteins. RNase 7 (R7) exhibits antimicrobial and immunomodulatory activities and is upregulated in the lesional skin of atopic dermatitis and psoriasis patients. Here, we performed mRNA microarray analysis to study the influence of R7 on gene expression in human keratinocytes. R7 induced several genes encoding proteins potentially involved in skin integrity and inflammation, including IL-24. Since IL-24 is involved in the pathogenesis of inflammatory skin diseases and since it is induced by IL-6, we further characterized the effect of R7 on IL-6 and IL-24 expression and secretion. R7 increased the release of the cytokines IL-6 and IL-24 by keratinocytes. Using a function-blocking antibody against IL-6 we showed that the R7-induced IL-24 secretion was triggered by IL-6. IL-6 released from R7-stimulated keratinocytes induced STAT3 signaling in target keratinocytes, suggesting a potential pathway resulting in IL-24 induction. Pre-stimulation with IL-17 or IFN-γ, cytokines involved in the pathogenesis of psoriasis, further enhanced R7-induced IL-6 secretion. R7 increased IL-6 secretion mainly from undifferentiated keratinocytes, suggesting that in the epidermis, R7 released from the stratum granulosum may induce expression and secretion of cytokines from basal undifferentiated keratinocytes. In conclusion, our data show that R7 enhances the release of IL-6 in undifferentiated primary keratinocytes, which may have consequences for skin inflammation, defense against pathogens, and wound healing.
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