ArticleScientific reports2025
A tryptophol-containing emulgel ameliorates imiquimod-induced mice psoriasis.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Pink lotus flower (Biomedical reports · 2026Article
- Low molecular weight sulfated galactan attenuates imiquimod-induced psoriasis via suppression of proinflammatory cytokines and keratinocyte hyperproliferation.Biomedical reports · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
Tryptophol (TOH) is an aromatic alcohol, a natural compound, which is produced by various microorganisms. TOH has been reported to have sleep-inducing effects, anti-microbial activities as well as immunoregulatory properties. While TOH was shown to suppress proinflammatory cytokine production in a variety of cell types, in vivo evidence supporting the immunosuppressive effect of TOH remains sparse. Here, we report that TOH reduced the severity of skin inflammation in a mouse model of imiquimod (IMQ)-induced psoriasis. The results revealed that the TOH-containing emulgel decreased the pathological score of the psoriasis area and severity index (PASI). Topical administration of TOH-containing emulgel inhibited keratinocyte proliferation in IMQ-treated skin as indicated by reduced immunoreactivity for Ki67 and decreased mRNA expression of K6, K16 and K17. Skin of TOH-containing emulgel-treated IMQ mice displayed fewer Giemsa-positive cells and CD4
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