Evidence map›Paper›PMID 40461655›Full record

ArticleNature biomedical engineering2025

NAD

Yao Lei, Yuzhu Wu, Wan-Ru Zhuang, Helin Zhao, Weidong Nie, Guanghao Wu, Dai-Wen Pang, Hai-Yan Xie

Abstract read
PubMed Publisher
In one paragraph

Article in Nature biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yao LeiState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Chemical Biology Center, Peking University, Beijing, P. R. China.
Yuzhu WuSchool of Life Science, Beijing Institute of Technology, Beijing, P. R. China.
Wan-Ru ZhuangState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Chemical Biology Center, Peking University, Beijing, P. R. China.
Helin ZhaoSchool of Life Science, Beijing Institute of Technology, Beijing, P. R. China.
Weidong NieSchool of Life Science, Beijing Institute of Technology, Beijing, P. R. China.
Guanghao WuSchool of Medical Technology, Beijing Institute of Technology, Beijing, P. R. China.
Dai-Wen PangCollege of Chemistry, Nankai University, Tianjin, P. R. China. dwpang@whu.edu.cn.ORCID http://orcid.org/0000-0002-7017-5725
Hai-Yan XieState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Chemical Biology Center, Peking University, Beijing, P. R. China. hyanxie@bjmu.edu.cn.ORCID http://orcid.org/0009-0008-8208-7168

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22025401,22293034, 22293030, 32101140, 22104005
6 · The paper itself

Abstract

Acute kidney injury (AKI) impairs the energy metabolism and antioxidant capacity of renal proximal tubular cells. Here we show that ultrasound-responsive liposomes integrating thylakoid fragments and encapsulating L-ascorbic acid can restore the energy supply and antioxidant capacity of the tubular cells as well as renal function in animal models of AKI. After intravenous injection, the liposomes preferentially accumulated in the injured kidneys and were internalized by proximal tubular cells. Quinolinate phosphoribosyltransferase expressed in thylakoid catalysed the biosynthesis of nicotinamide adenine dinucleotide (NAD

Indexed as

Acute Kidney InjuryLiposomesMitochondriaNADUltrasonic WavesAnimalsAntioxidantsAscorbic AcidKidneyMaleMiceMice, Inbred C57BLReactive Oxygen SpeciesSwineAntioxidantsAscorbic AcidLiposomesNADReactive Oxygen Species

Identifiers

PMID40461655

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.